Hydrogel Foams Containing Superabsorbent Particles for Wound Care Applications.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2025-05-23 DOI:10.1021/acsabm.4c01719

Nora Bastida Agote, Alessandro Cianciosi, Andrea Ewald, Jürgen Groll, Toby A Jenkins, Markus J Kettel

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引用次数: 0

Abstract

Herein, we report an innovative approach to design hydrogel foams by embedding superabsorbent polymer (SAP) particles with the aim of improving wound dressing applications. A cross-linking process was used to prepare hydrogel foams by just adding 3 components: an NCO-terminated three-arm prepolymer, SAP particles, and water. Variations in the chemical compositions allow creation of hydrogel foams with different material properties that can be applied to wounds with different characteristics. Hydrogel foams that are stable to electron beam sterilization are mechanically stable and have adjustable as well as very high absorption capacities. SAP-loaded foams have open pore structures and can be used to remove excess exudate from highly exudating wounds. Additionally, the SAP-loaded hydrogels have tunable high moisture donation properties and, hence, the potential to help keep contaminated wounds clean or to moisten a dry wound to enhance wound healing. Therefore, hydrogel foams with SAP particles have the potential to be used in advanced wound dressings for application on both dry and highly exudating, acute, and chronic wounds.

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水凝胶泡沫含有高吸水性颗粒的伤口护理应用。

在此，我们报告了一种创新的方法，通过嵌入高吸水性聚合物（SAP）颗粒来设计水凝胶泡沫，旨在改善伤口敷料的应用。采用交联工艺制备水凝胶泡沫，只需加入3种组分：端接nco的三臂预聚物、SAP颗粒和水。化学成分的变化允许创造具有不同材料特性的水凝胶泡沫，可以应用于不同特征的伤口。对电子束灭菌稳定的水凝胶泡沫具有机械稳定性，并且具有可调节的吸收能力以及非常高的吸收能力。含有sap的泡沫具有开放的孔隙结构，可用于从高度渗出的伤口中去除多余的渗出物。此外，sap负载的水凝胶具有可调的高水分捐赠特性，因此，有助于保持污染伤口清洁或湿润干燥伤口以促进伤口愈合的潜力。因此，具有SAP颗粒的水凝胶泡沫具有用于高级伤口敷料的潜力，可用于干燥和高度渗出，急性和慢性伤口。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.