Global Research Trends and Hotspots in the Role of Cholesterol in Colorectal Cancer: A Bibliometric Analysis

IF 3.3 2区医学 Q2 GENETICS & HEREDITY

Human Mutation Pub Date : 2025-05-24 DOI:10.1155/humu/6546114

Jun Pu, Yamin Zhao, Yu Wu, Tianqi Wu, Yue Ben, Yuting Sun, Jue Gu

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引用次数: 0

Abstract

Background: Cholesterol metabolism is important in colorectal cancer (CRC) pathogenesis, influencing tumorigenesis and therapeutic responses. Despite extensive research, fragmented insights and a lack of systematic analysis hinder the identification of global trends, collaboration networks, and emerging hotspots in this rapidly evolving field.

Methods: A bibliometric analysis of 1532 publications (2003–2024) from the Web of Science Core Collection was conducted using VOSviewer, CiteSpace, and R software. Metrics included publication trends, country/institution contributions, author networks, journal influence, keyword co-occurrence, and citation bursts.

Results: Global publications exhibited exponential growth, peaking at 114 in 2024. The United States (347 articles, 17,613 citations) and China (316 articles) dominated research output, yet institutional collaboration remained limited. Key journals included PLOS One and Cancer Research. Keyword evolution shifted from “physical activity” and “carcinogenesis” to “cholesterol metabolism,” “gut microbiota,” and “nanomedicine.” Statins showed preventive potential but raised concerns with prolonged use. Mechanistic insights highlighted nanoparticle-driven therapies as promising strategies to enhance chemosensitivity and reverse immunosuppression.

Conclusion: This inaugural comprehensive bibliometric analysis delineates the current research landscape of cholesterol in CRC, with particular emphasis on elucidating metabolic reprogramming mechanisms and fostering cross-disciplinary convergence. Future priorities include validating statins’ efficacy via randomized trials, leveraging multiomics for personalized therapies, and fostering global collaboration to address geographic disparities and translational challenges.

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胆固醇在结直肠癌中的作用的全球研究趋势和热点：文献计量学分析

背景：胆固醇代谢在结直肠癌（CRC）发病、肿瘤发生和治疗反应中起重要作用。尽管进行了广泛的研究，但零散的见解和缺乏系统的分析阻碍了对这一快速发展领域的全球趋势、协作网络和新兴热点的识别。方法：采用VOSviewer、CiteSpace和R软件对Web of Science Core Collection 2003-2024年1532篇论文进行文献计量学分析。指标包括出版趋势、国家/机构贡献、作者网络、期刊影响力、关键词共现和引文爆发。结果：全球出版物呈指数增长，2024年达到114篇。美国（347篇，17613次引用）和中国（316篇）主导了研究产出，但机构合作仍然有限。主要期刊包括PLOS One和Cancer Research。关键词进化从“体育活动”和“致癌作用”转变为“胆固醇代谢”、“肠道微生物群”和“纳米药物”。他汀类药物具有预防作用，但长期使用会引起人们的担忧。机制方面的见解强调了纳米颗粒驱动疗法作为提高化学敏感性和逆转免疫抑制的有希望的策略。结论：这项首次全面的文献计量分析描述了CRC中胆固醇的当前研究前景，特别强调阐明代谢重编程机制和促进跨学科融合。未来的优先事项包括通过随机试验验证他汀类药物的疗效，利用多组学进行个性化治疗，以及促进全球合作以解决地理差异和转化挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Mutation 医学-遗传学

CiteScore

8.40

自引率

5.10%

发文量

190

审稿时长

2 months

期刊介绍： Human Mutation is a peer-reviewed journal that offers publication of original Research Articles, Methods, Mutation Updates, Reviews, Database Articles, Rapid Communications, and Letters on broad aspects of mutation research in humans. Reports of novel DNA variations and their phenotypic consequences, reports of SNPs demonstrated as valuable for genomic analysis, descriptions of new molecular detection methods, and novel approaches to clinical diagnosis are welcomed. Novel reports of gene organization at the genomic level, reported in the context of mutation investigation, may be considered. The journal provides a unique forum for the exchange of ideas, methods, and applications of interest to molecular, human, and medical geneticists in academic, industrial, and clinical research settings worldwide.