Functionalized Organosilicon Material as a Potential Support for the Loading of Active Compounds

IF 2.8 3区材料科学 Q3 CHEMISTRY, PHYSICAL

Silicon Pub Date : 2025-03-28 DOI:10.1007/s12633-025-03293-9

Elizaveta A. Lantsova, Violetta A. Pertseva, Vitaliy N. Soromotin, Evgenia A. Saverina, Olga A. Kamanina

{"title":"Functionalized Organosilicon Material as a Potential Support for the Loading of Active Compounds","authors":"Elizaveta A. Lantsova, Violetta A. Pertseva, Vitaliy N. Soromotin, Evgenia A. Saverina, Olga A. Kamanina","doi":"10.1007/s12633-025-03293-9","DOIUrl":null,"url":null,"abstract":"<div><p>In this study, the yeast strain <i>Ogataea polymorpha</i> VKM Y-2559 was immobilized in an organosilicon matrix with varying volume ratios of aminopropyltriethoxysilane (APTES) and tetraethoxysilane (TEOS) in order to create a surface with functional groups. The architecture of the resulting materials and the elemental distribution on their surfaces were established. The efficiency of immobilization was determined by measuring the catalytic activity of yeast cells using a biosensor method with a Clark electrode. It was demonstrated that the optimal ratio for the encapsulation of yeast cells is a matrix comprising 5 to 95 vol. % APTES and 95 to 5 vol. % TEOS. The removal of yeast cells by solvent from the formed material allows the creation of a loading platform with a developed system of through pores for the sorption of biologically active substances. Moreover, the surface of the platform will contain amino groups that can be attached to quaternary ammonium compounds. The resulting material may prove to be of practical importance in the formation of porous systems for drug delivery and antibacterial materials that combine both the principle of desorption of the active substance and the contact-destroying action of the agent attached to the functionalized surface.</p></div>","PeriodicalId":776,"journal":{"name":"Silicon","volume":"17 7","pages":"1611 - 1623"},"PeriodicalIF":2.8000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Silicon","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s12633-025-03293-9","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

In this study, the yeast strain Ogataea polymorpha VKM Y-2559 was immobilized in an organosilicon matrix with varying volume ratios of aminopropyltriethoxysilane (APTES) and tetraethoxysilane (TEOS) in order to create a surface with functional groups. The architecture of the resulting materials and the elemental distribution on their surfaces were established. The efficiency of immobilization was determined by measuring the catalytic activity of yeast cells using a biosensor method with a Clark electrode. It was demonstrated that the optimal ratio for the encapsulation of yeast cells is a matrix comprising 5 to 95 vol. % APTES and 95 to 5 vol. % TEOS. The removal of yeast cells by solvent from the formed material allows the creation of a loading platform with a developed system of through pores for the sorption of biologically active substances. Moreover, the surface of the platform will contain amino groups that can be attached to quaternary ammonium compounds. The resulting material may prove to be of practical importance in the formation of porous systems for drug delivery and antibacterial materials that combine both the principle of desorption of the active substance and the contact-destroying action of the agent attached to the functionalized surface.

查看原文本刊更多论文

功能化有机硅材料作为负载活性化合物的潜在载体

本研究将酵母株Ogataea polymorpha VKM Y-2559固定在不同体积比的氨基丙基三乙氧基硅烷（APTES）和四乙氧基硅烷（TEOS）有机硅基质中，以形成具有官能团的表面。建立了所得材料的结构及其表面的元素分布。固定化效率是通过使用生物传感器法和Clark电极测量酵母细胞的催化活性来确定的。结果表明，酵母细胞包封的最佳比例是含有5% ~ 95% APTES和95% ~ 5% TEOS的基质。通过溶剂从形成的材料中去除酵母细胞，可以创建一个装载平台，该平台具有用于吸附生物活性物质的发达的通孔系统。此外，平台的表面将包含可以附着在季铵化合物上的氨基。所得到的材料可能被证明在形成用于药物递送和抗菌材料的多孔系统中具有实际重要性，该多孔系统结合了活性物质的解吸原理和附着在功能化表面上的试剂的接触破坏作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Silicon CHEMISTRY, PHYSICAL-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

5.90

自引率

20.60%

发文量

685

审稿时长

>12 weeks

期刊介绍： The journal Silicon is intended to serve all those involved in studying the role of silicon as an enabling element in materials science. There are no restrictions on disciplinary boundaries provided the focus is on silicon-based materials or adds significantly to the understanding of such materials. Accordingly, such contributions are welcome in the areas of inorganic and organic chemistry, physics, biology, engineering, nanoscience, environmental science, electronics and optoelectronics, and modeling and theory. Relevant silicon-based materials include, but are not limited to, semiconductors, polymers, composites, ceramics, glasses, coatings, resins, composites, small molecules, and thin films.