3D printing of PCL-based composite scaffolds coated with mesoporous bioactive glass nanoparticles (MBGNs) incorporating boron and molybdenum for ion-assisted bone tissue engineering

IF 3.5 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Journal of Materials Science Pub Date : 2025-05-14 DOI:10.1007/s10853-025-10900-y

Qaisar Nawaz, Gerard Blanco López, Till Strunk, Christian Damiani, Carlos Mas-Moruno, Fabian Westhauser, Martin Michalek, Nurshen Mutlu, Aldo R. Boccaccini

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引用次数: 0

Abstract

A new family of composite scaffolds based on polycaprolactone (PCL) and mesoporous bioactive glass nanoparticles (MBGNs) were 3D-printed. These printed scaffolds were further coated by boron and molybdenum doped MBGNs. The scaffolds were characterized in terms of microstructure, hydrophilicity, bioactivity and cytocompatibility. The scaffolds exhibited well-defined pore geometries characterized by layer-by-layer microscale struts. MBGNs coatings increased the hydrophilicity of the PCL scaffolds. A burst release of silicon within the first 48 h (100 ppm cumulative) was observed, indicating the fast dissolution/degradation of MBGNs. In contrast, the release of other ions such as calcium, boron and molybdenum was found to be lower, which is associated with their lower doping levels in the MBGNs silica matrix. In vitro experiments showed that MBGNs (doped and non-doped) enhanced the adhesion and proliferation of MC3T3-E1 cells; these positive biological outcomes were correlated with the release and biological activity of inorganic ions. The results thus demonstrate the potential of the composite scaffolds as suitable candidates for bone tissue engineering.

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含硼和钼的介孔生物活性玻璃纳米颗粒（MBGNs）涂层的pcl基复合支架的3D打印用于离子辅助骨组织工程

以聚己内酯（PCL）和介孔生物活性玻璃纳米颗粒（MBGNs）为基础，3d打印了一种新型复合支架。这些打印的支架进一步包被硼和钼掺杂的MBGNs。从微观结构、亲水性、生物活性和细胞相容性等方面对支架进行了表征。支架具有明确的孔隙几何形状，其特征是一层一层的微尺度支柱。MBGNs涂层提高了PCL支架的亲水性。在前48小时内观察到硅的爆发释放（累积100 ppm），表明MBGNs的快速溶解/降解。相比之下，其他离子如钙、硼和钼的释放量较低，这与它们在MBGNs二氧化硅基体中的掺杂水平较低有关。体外实验表明，掺杂和未掺杂MBGNs均能增强MC3T3-E1细胞的粘附和增殖；这些积极的生物学结果与无机离子的释放和生物活性有关。结果表明复合支架作为骨组织工程的合适候选材料的潜力。

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来源期刊

Journal of Materials Science 工程技术-材料科学：综合

CiteScore

7.90

自引率

4.40%

发文量

1297

审稿时长

2.4 months

期刊介绍： The Journal of Materials Science publishes reviews, full-length papers, and short Communications recording original research results on, or techniques for studying the relationship between structure, properties, and uses of materials. The subjects are seen from international and interdisciplinary perspectives covering areas including metals, ceramics, glasses, polymers, electrical materials, composite materials, fibers, nanostructured materials, nanocomposites, and biological and biomedical materials. The Journal of Materials Science is now firmly established as the leading source of primary communication for scientists investigating the structure and properties of all engineering materials.