Making field effect transistor measurements accessible to electrochemists and biologists

IF 2.6 4区 化学 Q3 ELECTROCHEMISTRY
Rupali Bagale, Subhankar Sahu, Francesco Basini, Marcin Szymon Filipiak, David Montaigne, Christophe Ritzenthaler, Henri Happy, Christophe Kleber, Rabah Boukherroub, Wolfgang Knoll, Roberto Corradini, Sabine Szunerits
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引用次数: 0

Abstract

Field effect transistors (FETs), originally developed in the field of electronic engineering, have gained increasing prominence in biosensing due to their versatile operation characteristics, ranging from recording simple electrical transfer curves to performing chronoamperometric measurements. Commonly known as bioFETs, these devices typically feature low gate voltage operation characteristics, can be made highly selective/sensitive through bioreceptor integration, label-free and do not rely on redox mediators or enzymatic product detection, and are easy to interface with microfluidic or flow cell devices. Despite their advantages, electrochemists and biologists remain still hesitant to explore the possibilities of bioFETs, owing to concerns about investment costs and the complexity of the read-out tools. In this study, we demonstrate the use of a simple, cost-effective bipotentiostat platform, providing an accessible solution for those interested in electronic biosensing without the need to delve into complex electronics. As a proof-of-concept, we showcase the working principle of a graphene-based bioFET for sensing a cardiac biomarker using a peptide nucleic acid (PNA)-aptamer-modified gFET platform. This article focuses on how to easily develop/operate FETs for biosensing measurements using the bipotentiostat-setup and discloses its simplicity over the conventional approaches.

使电场化学家和生物学家可以进行场效应晶体管测量
场效应晶体管(fet)最初是在电子工程领域发展起来的,由于其多功能的工作特性,从记录简单的电传递曲线到执行计时安培测量,在生物传感领域获得了越来越突出的地位。这些器件通常被称为生物场效应管(biofet),具有低栅极电压操作特性,可以通过生物受体集成实现高选择性/敏感性,无需标记,不依赖于氧化还原介质或酶促产物检测,并且易于与微流体或流动细胞设备接口。尽管生物场效应管有诸多优势,但由于担心投资成本和读出工具的复杂性,电化学家和生物学家仍然对探索生物场效应管的可能性犹豫不决。在这项研究中,我们展示了一个简单的,具有成本效益的双恒电位器平台的使用,为那些对电子生物传感感兴趣的人提供了一个可访问的解决方案,而无需深入研究复杂的电子学。作为概念验证,我们展示了使用肽核酸(PNA)-适配体修饰的gFET平台检测心脏生物标志物的石墨烯基生物ofet的工作原理。本文重点介绍了如何使用双电位器装置轻松开发/操作用于生物传感测量的场效应管,并揭示了其比传统方法的简单性。
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来源期刊
CiteScore
4.80
自引率
4.00%
发文量
227
审稿时长
4.1 months
期刊介绍: The Journal of Solid State Electrochemistry is devoted to all aspects of solid-state chemistry and solid-state physics in electrochemistry. The Journal of Solid State Electrochemistry publishes papers on all aspects of electrochemistry of solid compounds, including experimental and theoretical, basic and applied work. It equally publishes papers on the thermodynamics and kinetics of electrochemical reactions if at least one actively participating phase is solid. Also of interest are articles on the transport of ions and electrons in solids whenever these processes are relevant to electrochemical reactions and on the use of solid-state electrochemical reactions in the analysis of solids and their surfaces. The journal covers solid-state electrochemistry and focusses on the following fields: mechanisms of solid-state electrochemical reactions, semiconductor electrochemistry, electrochemical batteries, accumulators and fuel cells, electrochemical mineral leaching, galvanic metal plating, electrochemical potential memory devices, solid-state electrochemical sensors, ion and electron transport in solid materials and polymers, electrocatalysis, photoelectrochemistry, corrosion of solid materials, solid-state electroanalysis, electrochemical machining of materials, electrochromism and electrochromic devices, new electrochemical solid-state synthesis. The Journal of Solid State Electrochemistry makes the professional in research and industry aware of this swift progress and its importance for future developments and success in the above-mentioned fields.
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