The additive manufacturing NiTi alloy surface modification scheme can be used for photothermal treatment and overcoming implant infection

IF 23.2 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Advanced Composites and Hybrid Materials Pub Date : 2025-05-24 DOI:10.1007/s42114-025-01326-w

Yanan Yang, Zezhou Xu, Pengwei Sha, Panpan Li, Zhimin Xu, Yunting Guo, Zhenglei Yu, Zhihui Zhang, Luquan Ren

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引用次数: 0

Abstract

NiTi alloys produced through additive manufacturing technology exhibit unique shape memory effects and the capability to accurately form complex structures, making them promising materials for bone implants. However, the bioinert nature of NiTi alloys and their limited antibacterial properties increase the risk of implant loosening and infection following surgery, complicating treatment efforts. To address this issue, we propose the development of a biocompatible and bacteriostatic DCPD-PCL-GO coating on the surface of alloy using electrochemical deposition and dip-pulling methods. This coating not only enhances corrosion resistance but also inhibits nickel ion release. We investigated the corrosion resistance, biocompatibility, and photothermal therapy (PTT) capabilities under near-infrared irradiation of composite coatings with varying graphene oxide content. The safe concentration of doped graphene oxide was ultimately determined. Our results indicated that doping with 150 mg of graphene oxide yielded the best corrosion resistance (3.8 ± 0.8 × 10⁻⁹ A/cm²) while maintaining a high cell survival rate (101%). Under near-infrared irradiation, the bacteriostatic rates against Staphylococcus aureus and Escherichia coli (in vivo and in vitro) exceeded 80%. Notably, the near-infrared-triggered bacteriostatic strategy demonstrated good biosafety in vivo settings, effectively reducing the inflammatory response while ensuring the safety of normal tissues. This modified method has an important application prospect in the photothermal treatment of postoperative infection.

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增材制造NiTi合金表面改性方案可用于光热治疗和克服种植体感染

通过增材制造技术生产的NiTi合金具有独特的形状记忆效应和精确形成复杂结构的能力，使其成为骨植入物的有前途的材料。然而，NiTi合金的生物惰性及其有限的抗菌性能增加了手术后植入物松动和感染的风险，使治疗工作复杂化。为了解决这一问题，我们提出采用电化学沉积和浸拉的方法在合金表面开发生物相容性和抑菌性的DCPD-PCL-GO涂层。该涂层不仅提高了耐腐蚀性，而且抑制了镍离子的释放。我们研究了不同氧化石墨烯含量的复合涂层在近红外照射下的耐腐蚀性、生物相容性和光热治疗（PTT）能力。最终确定了掺杂氧化石墨烯的安全浓度。我们的研究结果表明，掺杂150 mg氧化石墨烯可获得最佳的耐腐蚀性（3.8±0.8 × 10−9 A/cm2），同时保持较高的细胞存活率（101%）。在近红外照射下，对金黄色葡萄球菌和大肠杆菌（体内和体外）的抑菌率均超过80%。值得注意的是，近红外触发的抑菌策略在体内环境中表现出良好的生物安全性，有效地减少了炎症反应，同时确保了正常组织的安全性。该改进方法在术后感染光热治疗中具有重要的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Composites and Hybrid Materials Multiple-

CiteScore

26.00

自引率

21.40%

发文量

185

期刊介绍： Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.