Spectroelectrochemical properties of 8-aminoquinoline: voltammetric and computational studies

IF 2.6 4区化学 Q3 ELECTROCHEMISTRY

Journal of Solid State Electrochemistry Pub Date : 2025-03-19 DOI:10.1007/s10008-025-06267-4

M. Z. Wiloch, D. G. Piekarski, N. Baran, A. Kubas, M. Jönsson-Niedziółka

引用次数: 0

Abstract

8-Aminoquinoline (8AQ) is the building block for many medicinal molecules. However, the redox properties of 8AQ, which are important for understanding the redox stability of drugs based on 8AQ in the human body, have not been studied in detail before. We have used cyclic voltammetry and pulse voltammetric techniques to investigate the anodic as well as the cathodic electrochemical behavior of 8AQ in a wide pH range. We have also applied UV–Vis spectroscopy to get a better understanding of the deprotonation of 8AQ due to pH changes. In addition, quantum chemical studies exploring the energy landscapes of the possible oxidations and reductions were performed, advancing our understanding of the electrochemical phenomena. The results indicate that the oxidation pathway of 8AQ strongly depends on the pH of the solution while reduction occurs according to a single pathway.

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8-氨基喹啉的光谱电化学性质：伏安法和计算研究

8-氨基喹啉（8AQ）是许多药物分子的基本成分。然而，对于了解8AQ类药物在人体内的氧化还原稳定性至关重要的氧化还原性质，目前尚未有详细的研究。我们使用循环伏安法和脉冲伏安法研究了8AQ在宽pH范围内的阳极和阴极电化学行为。我们还应用了紫外可见光谱来更好地了解由于pH变化引起的8AQ的去质子化。此外，量子化学研究探索了可能的氧化和还原的能量景观，促进了我们对电化学现象的理解。结果表明，8AQ的氧化途径强烈依赖于溶液的pH值，而还原途径则是单一的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Solid State Electrochemistry 工程技术-电化学

CiteScore

4.80

自引率

4.00%

发文量

227

审稿时长

4.1 months

期刊介绍： The Journal of Solid State Electrochemistry is devoted to all aspects of solid-state chemistry and solid-state physics in electrochemistry. The Journal of Solid State Electrochemistry publishes papers on all aspects of electrochemistry of solid compounds, including experimental and theoretical, basic and applied work. It equally publishes papers on the thermodynamics and kinetics of electrochemical reactions if at least one actively participating phase is solid. Also of interest are articles on the transport of ions and electrons in solids whenever these processes are relevant to electrochemical reactions and on the use of solid-state electrochemical reactions in the analysis of solids and their surfaces. The journal covers solid-state electrochemistry and focusses on the following fields: mechanisms of solid-state electrochemical reactions, semiconductor electrochemistry, electrochemical batteries, accumulators and fuel cells, electrochemical mineral leaching, galvanic metal plating, electrochemical potential memory devices, solid-state electrochemical sensors, ion and electron transport in solid materials and polymers, electrocatalysis, photoelectrochemistry, corrosion of solid materials, solid-state electroanalysis, electrochemical machining of materials, electrochromism and electrochromic devices, new electrochemical solid-state synthesis. The Journal of Solid State Electrochemistry makes the professional in research and industry aware of this swift progress and its importance for future developments and success in the above-mentioned fields.