Emissive Covalent organic Frameworks: Hydrogen bond switch-driven metal ion sensing and Cellular imaging

IF 4.8 3区材料科学 Q1 CHEMISTRY, APPLIED

Microporous and Mesoporous Materials Pub Date : 2025-05-17 DOI:10.1016/j.micromeso.2025.113687

San-Min Si , Zhitao Wang , Yanju Huang , Xiu-Mei Li , Hui Li

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引用次数: 0

Abstract

Covalent organic frameworks (COFs) with highly conjugated π skeletons hold great promise for developing emissive materials. However, designing tunable and highly emissive COFs remains a significant challenge. In this study, we introduce hydrazone-linked COFs (HL-COF and HL-COF-OH) that exhibit exceptional and tunable emission properties through hydrogen bond interactions in their frameworks. Notably, the emission wavelengths of HL-COF and HL-COF-OH can be tuned from 473 nm (blue) to 536 nm (yellow) in water. HL-COF-OH demonstrates superior sensitivity and selectivity for metal ion sensing compared to HL-COF, owing to the presence of open hydrogen bonds. The detection limit for Cu²⁺ was reduced to 208 nmol, positioning it among the best-performing COFs reported to date. Additionally, these emissive COFs successfully detected Cu²⁺ in cells without causing cytotoxicity, marking a significant milestone in the field. This strategy opens new avenue for designing color-tunable emissive materials for biological applications.

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发射共价有机框架：氢键开关驱动的金属离子传感和细胞成像

具有高共轭π骨架的共价有机骨架（COFs）在开发发射材料方面具有很大的前景。然而，设计可调谐和高发射的COFs仍然是一个重大挑战。在本研究中，我们引入了通过框架中的氢键相互作用表现出特殊和可调发射特性的腙连接的COFs （HL-COF和hl - COFs - oh）。值得注意的是，HL-COF和HL-COF- oh在水中的发射波长可以从473 nm（蓝色）调谐到536 nm（黄色）。由于开放氢键的存在，HL-COF- oh对金属离子的敏感性和选择性优于HL-COF。Cu2+的检出限降至208 nmol，使其成为迄今为止报道的性能最好的COFs之一。此外，这些发射COFs成功地检测了细胞中的Cu2+而不会引起细胞毒性，这是该领域的一个重要里程碑。这一策略为设计用于生物应用的颜色可调发射材料开辟了新的途径。

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来源期刊

Microporous and Mesoporous Materials 化学-材料科学：综合

CiteScore

10.70

自引率

5.80%

发文量

649

审稿时长

26 days

期刊介绍： Microporous and Mesoporous Materials covers novel and significant aspects of porous solids classified as either microporous (pore size up to 2 nm) or mesoporous (pore size 2 to 50 nm). The porosity should have a specific impact on the material properties or application. Typical examples are zeolites and zeolite-like materials, pillared materials, clathrasils and clathrates, carbon molecular sieves, ordered mesoporous materials, organic/inorganic porous hybrid materials, or porous metal oxides. Both natural and synthetic porous materials are within the scope of the journal. Topics which are particularly of interest include: All aspects of natural microporous and mesoporous solids The synthesis of crystalline or amorphous porous materials The physico-chemical characterization of microporous and mesoporous solids, especially spectroscopic and microscopic The modification of microporous and mesoporous solids, for example by ion exchange or solid-state reactions All topics related to diffusion of mobile species in the pores of microporous and mesoporous materials Adsorption (and other separation techniques) using microporous or mesoporous adsorbents Catalysis by microporous and mesoporous materials Host/guest interactions Theoretical chemistry and modelling of host/guest interactions All topics related to the application of microporous and mesoporous materials in industrial catalysis, separation technology, environmental protection, electrochemistry, membranes, sensors, optical devices, etc.