Cardiometabolic determinants of aortic and carotid intima-media thickness in adolescence

IF 4.9 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Atherosclerosis Pub Date : 2025-05-21 DOI:10.1016/j.atherosclerosis.2025.120218

Tomi T. Laitinen , Hanna Mikola , Katja Pahkala , Juha Mykkänen , Suvi P. Rovio , Harri Niinikoski , Tapani Rönnemaa , Jorma S.A. Viikari , Antti Jula , Hanna Lagström , Pia Salo , Joel Nuotio , Mika Ala-Korpela , Markus Juonala , Costan G. Magnussen , Olli T. Raitakari

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引用次数: 0

Abstract

Background and aims

Comprehensive longitudinal data in healthy populations on cardiometabolic determinants of arterial intima-media thickness (IMT), especially aortic IMT, in adolescence are lacking. We aimed to examine in detail how cardiometabolic risk factors associate with aortic and carotid intima-media thickness (IMT) in adolescence.

Methods

Participants (n = 522) were healthy individuals from Special Turku Coronary Risk Factor Intervention Project. IMT of the abdominal aorta and common carotid artery was measured repeatedly with ultrasonography at the age of 11, 13, 15, 17 and 19 years. Data on cardiometabolic risk markers were available beginning from early childhood.

Results

Between ages 11 and 19 years, body mass index (BMI), waist circumference, systolic and diastolic blood pressure, serum total cholesterol, non-HDL-cholesterol, and apolipoprotein B levels, insulin and insulin resistance indicated by homeostasis model of insulin resistance (HOMA-IR), C-reactive protein, and smoking associated directly with aortic IMT. For carotid IMT, a direct association was found with BMI, waist circumference, systolic blood pressure and smoking. In multivariate analyses, BMI(β = 5.49, SE = 1.01, P < 0.0001) and HOMA-IR (β = 16.79, SE = 7.45, P = 0.02) remained as determinants of aortic IMT. Correspondingly, BMI(β = 1.78, SE = 0.42, P < 0.0001) and systolic blood pressure (β = 0.38, SE = 0.10, P = 0.0001) determined carotid IMT. Participants with longitudinal aortic or carotid IMT above/equal the 80th percentile had higher BMI measured from infancy than their peers with longitudinal IMT below the 80th percentile.

Conclusions

In adolescence, several cardiometabolic risk factors associate with aortic IMT while these links are less evident for carotid IMT. Aortic IMT may serve as a more sensitive marker than carotid IMT of early vascular remodeling.

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青少年主动脉和颈动脉内膜-中膜厚度的心脏代谢决定因素

背景和目的在健康人群中缺乏关于青少年动脉内膜-中膜厚度（IMT），特别是主动脉内膜-中膜厚度（IMT）的心脏代谢决定因素的综合纵向数据。我们的目的是详细研究青少年心脏代谢危险因素与主动脉和颈动脉内膜-中膜厚度（IMT）的关系。方法522例来自图尔库冠状动脉危险因素特别干预项目的健康人。分别于11岁、13岁、15岁、17岁和19岁时，用超声反复测量腹主动脉和颈总动脉的IMT。心脏代谢风险标志物的数据可以从儿童早期开始获得。结果11 ~ 19岁之间，体重指数（BMI）、腰围、收缩压和舒张压、血清总胆固醇、非高密度脂蛋白胆固醇和载脂蛋白B水平、胰岛素和胰岛素抵抗稳态模型（HOMA-IR）指示的胰岛素、c反应蛋白和吸烟与主动脉IMT直接相关。颈动脉IMT与BMI、腰围、收缩压和吸烟有直接关系。在多变量分析中，BMI(β = 5.49, SE = 1.01, P <；0.0001)和HOMA-IR （β = 16.79, SE = 7.45, P = 0.02）仍然是主动脉IMT的决定因素。相应的，BMI(β = 1.78, SE = 0.42, P <；0.0001)和收缩压（β = 0.38, SE = 0.10, P = 0.0001）决定颈动脉IMT。纵向主动脉或颈动脉IMT高于或等于第80百分位数的参与者，从婴儿期开始测量的BMI高于纵向IMT低于第80百分位数的同龄人。结论：在青少年时期，一些心脏代谢危险因素与主动脉IMT相关，而这些联系在颈动脉IMT中不太明显。与颈动脉IMT相比，主动脉IMT可能是早期血管重构更敏感的标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Atherosclerosis 医学-外周血管病

CiteScore

9.80

自引率

3.80%

发文量

1269

审稿时长

36 days

期刊介绍： Atherosclerosis has an open access mirror journal Atherosclerosis: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Atherosclerosis brings together, from all sources, papers concerned with investigation on atherosclerosis, its risk factors and clinical manifestations. Atherosclerosis covers basic and translational, clinical and population research approaches to arterial and vascular biology and disease, as well as their risk factors including: disturbances of lipid and lipoprotein metabolism, diabetes and hypertension, thrombosis, and inflammation. The Editors are interested in original or review papers dealing with the pathogenesis, environmental, genetic and epigenetic basis, diagnosis or treatment of atherosclerosis and related diseases as well as their risk factors.