Anti-transferrin receptor 1 antibody reduces angiotensin II-induced vascular remodeling

IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Yoshiro Naito , Takeshi Tsujino , Tadashi Matsuura , Masanori Asakura , Tohru Masuyama , Masaharu Ishihara
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引用次数: 0

Abstract

Aortic abundance of transferrin receptor 1 (TfR1), a cellular iron receptor, is increased in several vascular diseases; however, the effects of anti-TfR1 antibody on vascular diseases remains largely unknown. Herein, we investigated our hypothesis that anti-TfR1 antibody can attenuate vascular remodeling. Mice were infused with angiotensin II (AngII) to induce vascular remodeling with or without anti-TfR1 antibody. Notably, anti-TfR1 antibody attenuated vascular remodeling in mice with AngII infusion. Moreover, anti-TfR1 antibody suppressed AngII-induced proliferation and migration in cultured vascular smooth muscle cells. Thus, targeting TfR1 with an antibody may have therapeutic potential for vascular remodeling.
抗转铁蛋白受体1抗体减少血管紧张素ii诱导的血管重构
转铁蛋白受体1 (TfR1,一种细胞铁受体)的主动脉丰度在几种血管疾病中升高;然而,抗tfr1抗体在血管疾病中的作用在很大程度上仍然未知。在此,我们研究了我们的假设,即抗tfr1抗体可以减轻血管重构。小鼠注射血管紧张素II (AngII)诱导血管重构,无论是否有抗tfr1抗体。值得注意的是,抗tfr1抗体减轻了AngII输注小鼠的血管重构。此外,抗tfr1抗体可抑制血管平滑肌细胞的增殖和迁移。因此,用抗体靶向TfR1可能具有治疗血管重构的潜力。
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来源期刊
CiteScore
10.70
自引率
0.00%
发文量
171
审稿时长
42 days
期刊介绍: The Journal of Molecular and Cellular Cardiology publishes work advancing knowledge of the mechanisms responsible for both normal and diseased cardiovascular function. To this end papers are published in all relevant areas. These include (but are not limited to): structural biology; genetics; proteomics; morphology; stem cells; molecular biology; metabolism; biophysics; bioengineering; computational modeling and systems analysis; electrophysiology; pharmacology and physiology. Papers are encouraged with both basic and translational approaches. The journal is directed not only to basic scientists but also to clinical cardiologists who wish to follow the rapidly advancing frontiers of basic knowledge of the heart and circulation.
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