{"title":"Anti-transferrin receptor 1 antibody reduces angiotensin II-induced vascular remodeling","authors":"Yoshiro Naito , Takeshi Tsujino , Tadashi Matsuura , Masanori Asakura , Tohru Masuyama , Masaharu Ishihara","doi":"10.1016/j.yjmcc.2025.05.006","DOIUrl":null,"url":null,"abstract":"<div><div>Aortic abundance of transferrin receptor 1 (TfR1), a cellular iron receptor, is increased in several vascular diseases; however, the effects of anti-TfR1 antibody on vascular diseases remains largely unknown. Herein, we investigated our hypothesis that anti-TfR1 antibody can attenuate vascular remodeling. Mice were infused with angiotensin II (AngII) to induce vascular remodeling with or without anti-TfR1 antibody. Notably, anti-TfR1 antibody attenuated vascular remodeling in mice with AngII infusion. Moreover, anti-TfR1 antibody suppressed AngII-induced proliferation and migration in cultured vascular smooth muscle cells. Thus, targeting TfR1 with an antibody may have therapeutic potential for vascular remodeling.</div></div>","PeriodicalId":16402,"journal":{"name":"Journal of molecular and cellular cardiology","volume":"204 ","pages":"Pages 35-39"},"PeriodicalIF":4.9000,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of molecular and cellular cardiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022282825000884","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Aortic abundance of transferrin receptor 1 (TfR1), a cellular iron receptor, is increased in several vascular diseases; however, the effects of anti-TfR1 antibody on vascular diseases remains largely unknown. Herein, we investigated our hypothesis that anti-TfR1 antibody can attenuate vascular remodeling. Mice were infused with angiotensin II (AngII) to induce vascular remodeling with or without anti-TfR1 antibody. Notably, anti-TfR1 antibody attenuated vascular remodeling in mice with AngII infusion. Moreover, anti-TfR1 antibody suppressed AngII-induced proliferation and migration in cultured vascular smooth muscle cells. Thus, targeting TfR1 with an antibody may have therapeutic potential for vascular remodeling.
期刊介绍:
The Journal of Molecular and Cellular Cardiology publishes work advancing knowledge of the mechanisms responsible for both normal and diseased cardiovascular function. To this end papers are published in all relevant areas. These include (but are not limited to): structural biology; genetics; proteomics; morphology; stem cells; molecular biology; metabolism; biophysics; bioengineering; computational modeling and systems analysis; electrophysiology; pharmacology and physiology. Papers are encouraged with both basic and translational approaches. The journal is directed not only to basic scientists but also to clinical cardiologists who wish to follow the rapidly advancing frontiers of basic knowledge of the heart and circulation.