Aglutenic cupcakes for gastro-intestinal symptoms and hematological indices in diagnosed celiac children –A randomized trial

Q3 Nursing

Clinical Nutrition Open Science Pub Date : 2025-05-09 DOI:10.1016/j.nutos.2025.04.010

Shaista Jabeen , Azmat Ullah Khan

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引用次数: 0

Abstract

Fundamental adherence to gluten-free diet can improve gastrointestinal symptoms. Substitution of wheat should be done in order to fulfil gluten-free criteria and nutrient density.

Objective

This study was conducted to assess the efficacy of gluten free cupcakes formulated by substitution of low FODMAP foods.

Design

Random parallel assignment was adopted (1b).

Methods

A 12 weeks efficacy trial was conducted on children of age 3–8 years, and were randomly allocated into two groups (n = 35 in each group). Gluten free cupcakes group was provided with gluten-free flour blend cupcakes (35 g), while placebo group was provided with rice flour-based cupcakes.

Results

Weight was significantly increased in both placebo (13.7 ± 4.8 to 14.5 ± 4.4) and gluten free (13.6 ± 4.6 to 15.4 ± 4.6) groups. Mid upper arm circumference was significantly increased in gluten free group only (15.3 ± 3 to 15.5 ± 3). Abdominal pain was reduced to 38.7% from 6.5% (absent) in the placebo group compared to gluten free group 15.2%–33.3% (absent), while diarrhea was reduced to 33.3% from 27.3%. Serum platelets were significantly reduced in gluten free cupcake group (GFC) from 308.4 ± 39.5 to 300.3 ± 38.7 (P < 0.05). Tissue trans-glutaminase antibody (tTg-IgA) was significantly reduced from 148 ± 51 to 127 ± 31.

Conclusion

Formulated gluten-free cupcakes are found to be effective in improving gastrointestinal symptoms and anthropometrics in patients with celiac disease.

ClinicalTrials.gov PRS

Record Summary NCT06359613.

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促凝纸杯蛋糕对诊断为乳糜泻的儿童胃肠道症状和血液学指标的影响——一项随机试验

坚持无谷蛋白饮食可以改善胃肠道症状。为了满足无麸质标准和营养密度，应采用小麦替代。目的评价用低FODMAP食品替代无麸质纸杯蛋糕的效果。设计采用随机并行分配（1b）。方法对3 ~ 8岁儿童进行为期12周的疗效试验，随机分为两组，每组35例。无麸质蛋糕组提供无麸质面粉混合蛋糕（35 g），而安慰剂组提供米粉蛋糕。结果安慰剂组（13.7±4.8 ~ 14.5±4.4）和无麸质组（13.6±4.6 ~ 15.4±4.6）体重均显著增加。仅无麸质组上臂中部围度显著增加（15.3±3 ~ 15.5±3）。与无麸质组相比，安慰剂组腹痛从6.5%（无）减少到38.7%（无），而腹泻从27.3%减少到33.3%（无）。无麸质纸杯蛋糕组（GFC）血清血小板从308.4±39.5显著降低至300.3±38.7 (P <；0.05)。组织反式谷氨酰胺酶抗体（tTg-IgA）由148±51降至127±31。结论配方无麸质纸杯蛋糕可有效改善乳糜泻患者的胃肠道症状和人体测量学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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