Targeting tumor-associated macrophage polarization with traditional Chinese medicine active ingredients: Dual reversal of chemoresistance and immunosuppression in tumor microenvironment

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmacological research Pub Date : 2025-05-23 DOI:10.1016/j.phrs.2025.107788

Yafeng Qi , Jingnan Yan , Xixi Huang , Xiaodan Jiang , Rongrong Li , Jiayi Wan , Yangyang Li , Zhiming Miao , Zhongyang Song , Yongqi Liu , Liying Zhang , Zhiming Zhang

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引用次数: 0

Abstract

Chemotherapy resistance and immunosuppression are major causes of tumor treatment failure. The polarization state of tumor-associated macrophages (TAMs) is a central regulatory hub for both processes. Traditional Chinese medicine (TCM) has the characteristics of multi-component, multi-target, and multi-pathway. It regulating M1/M2 polarization is promising due to the high plasticity of TAMs. This review comprehensively explores the anti-tumor effects of TCM active components through multiple targets such as metabolic reprogramming. The mechanism includes regulating TAM's polarization, reversing chemotherapy resistance, and modulating immunosuppression. Furthermore, we also summarize the synergistic effects of TCM multi-component and the exploration of mechanisms promoted by new technologies. While most studies are still in the preclinical stage, these insights highlight the potential of TCM as a cancer treatment and highlight avenues for future research and clinical application to improve patient outcomes.

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中药有效成分靶向肿瘤相关巨噬细胞极化：肿瘤微环境化疗耐药和免疫抑制的双重逆转

化疗耐药和免疫抑制是肿瘤治疗失败的主要原因。肿瘤相关巨噬细胞（tam）的极化状态是这两个过程的中心调控枢纽。中医具有多成分、多靶点、多途径的特点。由于tam具有较高的可塑性，因此它对M1/M2极化的调节具有广阔的应用前景。本文从代谢重编程等多个靶点全面探讨了中药活性成分的抗肿瘤作用。其机制包括调节TAM极化、逆转化疗耐药、调节免疫抑制等。此外，我们还总结了中药多组分的协同作用和新技术推动的机制探索。虽然大多数研究仍处于临床前阶段，但这些见解突出了中医药作为癌症治疗的潜力，并为未来的研究和临床应用指明了改善患者预后的途径。

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.