Transcranial near infrared therapy reprograms metabolism to rescue sleep and place cell functionality

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-05-11 DOI:10.1016/j.isci.2025.112633

Yue Dong , Yuping Wang , Xiaoyun Liu , Yinchang Wang , Ziteng Yue , Zhanjing Wang , Sheng Wang

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引用次数: 0

Abstract

Sleep disturbances exacerbate Alzheimer’s disease (AD) pathology, accelerating cognitive decline and impairing hippocampal memory functions. This study explores the therapeutic potential of transcranial near-infrared (tNIR) therapy in mitigating hippocampal dysfunction caused by chronic sleep deprivation (SD) in a tauopathy mouse model of AD. Using targeted 808 nm tNIR therapy, we observed restored cerebral blood flow, enhanced metabolic reprogramming favoring oxidative phosphorylation, and reestablished ionic homeostasis. These effects improved hippocampal oscillatory dynamics, including enhanced theta, gamma, and delta power, synchronized sharp-wave ripples (SWRs), and improved the phase-locking of place cell activity to theta and awake SWR oscillations. tNIR therapy also refined spatial encoding precision and reorganized sleep architecture, promoting slow-wave sleep while reducing REM disturbances. These findings position tNIR therapy as a promising non-invasive approach for addressing SD-driven cognitive and neural impairments, offering a novel intervention for sleep-related neurodegeneration in AD.

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经颅近红外治疗重编程代谢，以挽救睡眠和位置细胞功能

睡眠障碍加剧阿尔茨海默病（AD）病理，加速认知衰退和损害海马记忆功能。本研究探讨经颅近红外（tNIR）治疗在缓解AD牛头病小鼠模型慢性睡眠剥夺（SD）引起的海马功能障碍中的治疗潜力。使用靶向808 nm tNIR治疗，我们观察到脑血流量恢复，有利于氧化磷酸化的代谢重编程增强，并重建离子稳态。这些效应改善了海马的振荡动力学，包括增强了theta、gamma和delta功率，同步锐波波纹（SWR），并改善了位置细胞活动到theta和清醒SWR振荡的锁相。tNIR疗法还改善了空间编码精度，重组了睡眠结构，促进了慢波睡眠，同时减少了REM干扰。这些发现表明，tNIR治疗是解决sd驱动的认知和神经损伤的一种有前途的非侵入性方法，为AD患者睡眠相关神经变性提供了一种新的干预手段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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