Autophagic impairment in endometrial polyps: A potential biomarker and therapeutic target

IF 2.7 4区生物学 Q1 ANATOMY & MORPHOLOGY

Tissue & cell Pub Date : 2025-05-17 DOI:10.1016/j.tice.2025.102978

Burak Sezgi̇n , Tuba Edgünlü , Özgür ilhan Çeli̇k , Nazlı Can , Ayşegül Demirtaş Bi̇lgi̇ç

{"title":"Autophagic impairment in endometrial polyps: A potential biomarker and therapeutic target","authors":"Burak Sezgi̇n , Tuba Edgünlü , Özgür ilhan Çeli̇k , Nazlı Can , Ayşegül Demirtaş Bi̇lgi̇ç","doi":"10.1016/j.tice.2025.102978","DOIUrl":null,"url":null,"abstract":"<div><div>Endometrial polyps are a common gynecological condition associated with abnormal uterine bleeding, infertility, and potential malignancies. This study investigated the expression of key autophagy proteins LC3A/B, p62, and Beclin-1 in endometrial polyps. Twenty patients with endometrial polyps and ten healthy controls were enrolled in a prospective randomized controlled trial. Tissue samples were collected via operative hysteroscopy. ELISA and immunohistochemistry were employed to assess the expression of LC3A/B, p62, and Beclin-1. While ELISA results did not reveal significant differences between the two groups, immunohistochemical analysis demonstrated significantly lower levels of LC3A/B, p62, and Beclin-1 in endometrial polyps compared to healthy endometrial tissue (p = 0.041, p = 0.012, and p = 0.003, respectively). These findings suggest that impaired autophagy, as evidenced by reduced levels of these key autophagy proteins, may contribute to the pathogenesis of endometrial polyps. Further research is needed to elucidate the precise mechanisms underlying this association and to explore potential therapeutic implications.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"96 ","pages":"Article 102978"},"PeriodicalIF":2.7000,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tissue & cell","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040816625002587","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ANATOMY & MORPHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Endometrial polyps are a common gynecological condition associated with abnormal uterine bleeding, infertility, and potential malignancies. This study investigated the expression of key autophagy proteins LC3A/B, p62, and Beclin-1 in endometrial polyps. Twenty patients with endometrial polyps and ten healthy controls were enrolled in a prospective randomized controlled trial. Tissue samples were collected via operative hysteroscopy. ELISA and immunohistochemistry were employed to assess the expression of LC3A/B, p62, and Beclin-1. While ELISA results did not reveal significant differences between the two groups, immunohistochemical analysis demonstrated significantly lower levels of LC3A/B, p62, and Beclin-1 in endometrial polyps compared to healthy endometrial tissue (p = 0.041, p = 0.012, and p = 0.003, respectively). These findings suggest that impaired autophagy, as evidenced by reduced levels of these key autophagy proteins, may contribute to the pathogenesis of endometrial polyps. Further research is needed to elucidate the precise mechanisms underlying this association and to explore potential therapeutic implications.

查看原文本刊更多论文

子宫内膜息肉的自噬损伤：一个潜在的生物标志物和治疗靶点

子宫内膜息肉是一种常见的妇科疾病，与子宫异常出血、不孕症和潜在的恶性肿瘤有关。本研究探讨了关键自噬蛋白LC3A/B、p62和Beclin-1在子宫内膜息肉中的表达。20名子宫内膜息肉患者和10名健康对照者参加了一项前瞻性随机对照试验。通过手术宫腔镜采集组织样本。ELISA和免疫组化检测LC3A/B、p62、Beclin-1的表达。虽然ELISA结果没有显示两组之间的显著差异，但免疫组织化学分析显示，与健康子宫内膜组织相比，子宫内膜息肉组织中LC3A/B、p62和Beclin-1的水平显著降低（p = 0.041,p = 0.012,p = 0.003）。这些发现表明，自噬受损，如这些关键自噬蛋白水平降低所证明的，可能有助于子宫内膜息肉的发病机制。需要进一步的研究来阐明这种关联的确切机制并探索潜在的治疗意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.