The value of LAR and IL-6 in early diagnosis and prognostic assessment of severe acute pancreatitis

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme Pub Date : 2025-05-16 DOI:10.1016/j.nupar.2025.04.002

Lin Xu , Meng Lin , Chao Liu , Guochao Zhu

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Abstract

To analyze the clinical value of lactate dehydrogenase to albumin ratio (LAR) and interleukin-6 (IL-6) in the early diagnosis and prognostic assessment of severe acute pancreatitis (SAP). A retrospective study was conducted on 98 cases of acute pancreatitis patients. These patients were divided into two groups based on the severity of their condition: non-SAP group (n = 68) and SAP group (n = 30). Spearman correlation analysis was utilized to investigate the correlation of LAR and IL-6 with the bedside index for severity in acute pancreatitis (BISAP). Patients in the SAP group exhibited significantly higher LAR values and IL-6 levels compared to those in the non-SAP group (P < 0.05). The APR and IL-6 of SAP patients were significantly positively correlated with BISAP scores (R = 0.758, P < 0.001) (R = 0.660, P < 0.001). The diagnostic AUC of LAR and IL-6 for SAP were 0.742 (P < 0.001) and 0.749 (P < 0.001), respectively. The Logistic regression analysis demonstrated that LAR and IL-6 were independent risk factors for SAP (P < 0.05). The levels of LAR and IL-6 in the death subgroup were significantly higher than those in the survival subgroup (P < 0.05). The diagnostic AUC of LAR and IL-6 for poor prognosis of SAP were 0.971 (P < 0.001) and 0.713 (P = 0.055), respectively. LAR was an independent risk factor for poor prognosis in SAP patients (P < 0.05). Patients with SAP may exhibit abnormally elevated levels of LAR and IL-6. LAR and IL-6 are closely associated with the severity of the patient's condition, which can be applied in the diagnosis of SAP.

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LAR和IL-6在重症急性胰腺炎早期诊断及预后评估中的价值

探讨乳酸脱氢酶与白蛋白比值（LAR）及白细胞介素-6 （IL-6）在重症急性胰腺炎（SAP）早期诊断及预后评估中的临床价值。对98例急性胰腺炎患者进行回顾性分析。这些患者根据病情严重程度分为两组：非SAP组（n = 68）和SAP组（n = 30）。采用Spearman相关分析探讨LAR和IL-6与急性胰腺炎严重程度床边指数（BISAP）的相关性。SAP组患者的LAR值和IL-6水平明显高于非SAP组(P <；0.05)。SAP患者APR、IL-6与BISAP评分呈显著正相关(R = 0.758, P <；0.001) (R = 0.660, P <；0.001)。LAR和IL-6对SAP的诊断AUC为0.742 (P <；0.001)和0.749 (P <；分别为0.001)。Logistic回归分析显示，LAR和IL-6是SAP的独立危险因素(P <；0.05)。死亡亚组LAR和IL-6水平显著高于生存亚组(P <；0.05)。LAR和IL-6对SAP预后不良的诊断AUC为0.971 (P <；0.001)和0.713 （P = 0.055）。LAR是SAP患者预后不良的独立危险因素(P <；0.05)。SAP患者可能表现为LAR和IL-6水平异常升高。LAR和IL-6与患者病情的严重程度密切相关，可用于SAP的诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Clinique et Metabolisme 医学-内分泌学与代谢

CiteScore

0.80

自引率

16.70%

发文量

216

审稿时长

78 days

期刊介绍： Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.