Mimicking the structure and function of tau folds associated with disease

IF 19.2 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nature chemistry Pub Date : 2025-05-23 DOI:10.1038/s41557-025-01841-9

Joost Schymkowitz, Frederic Rousseau

引用次数: 0

Abstract

Tauopathies are neurodegenerative diseases characterized by the pathological aggregation of tau, which forms distinct polymorphic structures in a disease-specific manner. A recent study presents macrocyclic tau-mimicking peptides that structurally and functionally resemble these disease-associated folds, providing new tools for studying tau aggregation and potential therapeutic strategies.

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模拟与疾病相关的tau折叠的结构和功能

tau病是一种神经退行性疾病，其特征是tau蛋白的病理聚集，以疾病特异性的方式形成不同的多态性结构。最近的一项研究提出了结构和功能类似于这些疾病相关折叠的大环tau模拟肽，为研究tau聚集和潜在的治疗策略提供了新的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature chemistry 化学-化学综合

CiteScore

29.60

自引率

1.40%

发文量

226

审稿时长

1.7 months

期刊介绍： Nature Chemistry is a monthly journal that publishes groundbreaking and significant research in all areas of chemistry. It covers traditional subjects such as analytical, inorganic, organic, and physical chemistry, as well as a wide range of other topics including catalysis, computational and theoretical chemistry, and environmental chemistry. The journal also features interdisciplinary research at the interface of chemistry with biology, materials science, nanotechnology, and physics. Manuscripts detailing such multidisciplinary work are encouraged, as long as the central theme pertains to chemistry. Aside from primary research, Nature Chemistry publishes review articles, news and views, research highlights from other journals, commentaries, book reviews, correspondence, and analysis of the broader chemical landscape. It also addresses crucial issues related to education, funding, policy, intellectual property, and the societal impact of chemistry. Nature Chemistry is dedicated to ensuring the highest standards of original research through a fair and rigorous review process. It offers authors maximum visibility for their papers, access to a broad readership, exceptional copy editing and production standards, rapid publication, and independence from academic societies and other vested interests. Overall, Nature Chemistry aims to be the authoritative voice of the global chemical community.