Doxorubicin Carrier Mediated by HCOF Platform for Potent Cancer Therapy

IF 3.5 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions Pub Date : 2025-05-23 DOI:10.1039/d5dt00486a

Tingyan Jiang, Meng Liu, jiarui Qiao, Wenjing Wei, Xianhao Wei, Luwen Zhang, yan wang, Junhe Ou, Maolin Pang

引用次数: 0

Abstract

Doxorubicin is widely used in cancer treatment, and an effective drug carrier is usually needed to overcome its serious side effects. In this study, highly monodisperse hollow covalent organic framework (HCOF) was prepared by a two-step method, then DOX was loaded with a high loading efficiency of 41.2 wt%. In vivo studies demonstrated excellent antitumor efficacy.

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HCOF平台介导的阿霉素载体有效治疗肿瘤

阿霉素广泛应用于癌症治疗，通常需要一种有效的药物载体来克服其严重的副作用。本研究采用两步法制备了高度单分散的空心共价有机骨架（HCOF），然后负载DOX，负载效率高达41.2%。体内研究表明其具有良好的抗肿瘤功效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dalton Transactions 化学-无机化学与核化学

CiteScore

6.60

自引率

7.50%

发文量

1832

审稿时长

1.5 months

期刊介绍： Dalton Transactions is a journal for all areas of inorganic chemistry, which encompasses the organometallic, bioinorganic and materials chemistry of the elements, with applications including synthesis, catalysis, energy conversion/storage, electrical devices and medicine. Dalton Transactions welcomes high-quality, original submissions in all of these areas and more, where the advancement of knowledge in inorganic chemistry is significant.