Sentinel Lymph Node Detection, Location, and Number on SPECT/CT Can Help Predict Pathological Axillary Lymph Node Metastasis in Women with Breast Cancer.

IF 1.4 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI:10.1272/jnms.JNMS.2025_92-208

Meishi Hankyo, Ryusuke Murakami, Hiroyuki Takei, Keiko Yanagihara, Tomoko Kurita, Takashi Sakatani, Ryuji Ohashi, Shinichiro Kumita

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引用次数: 0

Abstract

Background: Use of radiocolloids for sentinel lymph node (SLN) detection in breast cancer (BC) offers the advantage of utilizing single-photon emission computed tomography/computed tomography (SPECT/CT). This study explored whether SPECT/CT findings can predict pathological axillary lymph node (ALN) metastasis.

Methods: A consecutive series of patients with invasive BC (clinical stage, T1-3, N0, and M0) who underwent SLN biopsy (SLNB) using SPECT/CT between January 2011 and December 2016 were included. SLN detection, location, and number on SPECT/CT, number of excised SLNs, and clinical and pathological characteristics were analyzed in relation to pathological ALN metastasis.

Results: Data from 408 patients (412 cases) with BC were analyzed. Patient age ranged from 28 to 93 years (mean: 59). SPECT/CT identified one to four SLNs (mean: 1.3) in 407 cases (98.8%) and no SLNs in 5 cases (1.2%). Of the 407 cases with at least one identified SLN, SLNs were solely in level I of the axilla in 394 cases (96.8%), both in and outside level I in 12 (2.9%), and solely outside of level I in 1 (0.2%). The number of ALNs removed via SLNB ranged from one to eight (mean: 2.0). SPECT/CT findings, including absence of SLN detection (P<0.001), SLN locations outside of axillary level I (P<0.001), and an increased number of SLNs (P=0.034), as well as removal of ≥3 SLNs (P=0.028), were significantly correlated with pathological ALN metastasis.

Conclusions: SLNB with SPECT/CT yields useful information on pathological ALN metastasis in BC patients.

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SPECT/CT前哨淋巴结的检测、位置和数量有助于预测乳腺癌患者腋窝淋巴结的病理转移。

背景：使用放射性胶体进行乳腺癌前哨淋巴结（SLN）检测具有单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）的优势。本研究探讨SPECT/CT表现能否预测病理性腋窝淋巴结（ALN）转移。方法：选取2011年1月至2016年12月期间连续接受SPECT/CT SLN活检（SLNB）的浸润性BC患者（临床分期T1-3、N0和M0）。分析SLN在SPECT/CT上的检测、位置、数量、切除的SLN数量、临床及病理特征与ALN病理转移的关系。结果：分析了408例（412例）BC患者的数据。患者年龄28 ~ 93岁（平均59岁）。407例（98.8%）SPECT/CT检出1 ~ 4个sln（平均1.3个），5例（1.2%）未检出sln。在407例至少有一种SLN的病例中，394例（96.8%）SLN仅在腋窝I级，12例（2.9%）在I级内和I级外，1例（0.2%）仅在I级外。通过SLNB去除的aln数量从1到8不等（平均值：2.0）。结论：SLNB与SPECT/CT结合可提供BC患者ALN病理转移的有用信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nippon Medical School MEDICINE, GENERAL & INTERNAL-

CiteScore

1.80

自引率

10.00%

发文量

118

期刊介绍： The international effort to understand, treat and control disease involve clinicians and researchers from many medical and biological science disciplines. The Journal of Nippon Medical School (JNMS) is the official journal of the Medical Association of Nippon Medical School and is dedicated to furthering international exchange of medical science experience and opinion. It provides an international forum for researchers in the fields of bascic and clinical medicine to introduce, discuss and exchange thier novel achievements in biomedical science and a platform for the worldwide dissemination and steering of biomedical knowledge for the benefit of human health and welfare. Properly reasoned discussions disciplined by appropriate references to existing bodies of knowledge or aimed at motivating the creation of such knowledge is the aim of the journal.