Shenghai Huang, Haisi Chen, Weiwei Zheng, Bing Lin
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引用次数: 0
Abstract
Purpose: To investigate the impact of myopic changes on diabetic retinopathy (DR) progression by comparing ETDRS grading scores and optical coherence tomography (OCT) biomarkers between the eyes with anisometropia.
Method: This observational cross-sectional study retrospectively reviewed clinical records of anisometropia patients with DR. ETDRS grading scores and OCT biomarkers, including central subfield thickness (CST), subfoveal choroidal thickness (SFCT), presence of subretinal fluid (SRF), cystoid changes in the outer nuclear layer (ONL) and inner nuclear layer (INL), hyperreflective foci (HRF), ellipsoid zone (EZ) continuity, the continuity of the external limiting membrane (ELM), disorganization of retinal inner layers (DRIL) and vitreomacular interface changes, were analyzed between the lower and higher diopter eyes. Correlations among binocular differences in spherical equivalent refraction (SER), SFCT, and ETDRS grading scores were examined.
Results: Lower diopter eyes had significantly lower ETDRS scores (35.3 ± 14.5 vs. 54.4 ± 21.3, P < 0.001) and thinner SFCT (153.0 ± 109.4 μm vs. 235.6 ± 107.2 μm, P < 0.001) compared to higher diopter eyes. Lower diopter eyes exhibited fewer cystoid spaces in the ONL, reduced HRF, less DRIL and less disruption of the EZ. Significant positive correlations were found between binocular differences in SER and ETDRS scores (ρ = 0. 789, P < 0.001), SFCT and ETDRS scores (ρ = 0. 726, P < 0.001), and SER and SFCT (ρ = 0. 719, P < 0.001).
Conclusion: Myopia appears to have a protective effect against DR progression in anisometropia, as indicated by lower ETDRS scores and favorable OCT biomarkers.
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