Impact of Anisometropia on Diabetic Retinopathy Progression: The Role of Optical Coherence Tomography Biomarkers.

IF 2.1 2区 医学 Q2 OPHTHALMOLOGY
Shenghai Huang, Haisi Chen, Weiwei Zheng, Bing Lin
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引用次数: 0

Abstract

Purpose: To investigate the impact of myopic changes on diabetic retinopathy (DR) progression by comparing ETDRS grading scores and optical coherence tomography (OCT) biomarkers between the eyes with anisometropia.

Method: This observational cross-sectional study retrospectively reviewed clinical records of anisometropia patients with DR. ETDRS grading scores and OCT biomarkers, including central subfield thickness (CST), subfoveal choroidal thickness (SFCT), presence of subretinal fluid (SRF), cystoid changes in the outer nuclear layer (ONL) and inner nuclear layer (INL), hyperreflective foci (HRF), ellipsoid zone (EZ) continuity, the continuity of the external limiting membrane (ELM), disorganization of retinal inner layers (DRIL) and vitreomacular interface changes, were analyzed between the lower and higher diopter eyes. Correlations among binocular differences in spherical equivalent refraction (SER), SFCT, and ETDRS grading scores were examined.

Results: Lower diopter eyes had significantly lower ETDRS scores (35.3 ± 14.5 vs. 54.4 ± 21.3, P < 0.001) and thinner SFCT (153.0 ± 109.4 μm vs. 235.6 ± 107.2 μm, P < 0.001) compared to higher diopter eyes. Lower diopter eyes exhibited fewer cystoid spaces in the ONL, reduced HRF, less DRIL and less disruption of the EZ. Significant positive correlations were found between binocular differences in SER and ETDRS scores (ρ = 0. 789, P < 0.001), SFCT and ETDRS scores (ρ = 0. 726, P < 0.001), and SER and SFCT (ρ = 0. 719, P < 0.001).

Conclusion: Myopia appears to have a protective effect against DR progression in anisometropia, as indicated by lower ETDRS scores and favorable OCT biomarkers.

屈光参差对糖尿病视网膜病变进展的影响:光学相干断层扫描生物标志物的作用。
目的:通过比较ETDRS评分和光学相干断层扫描(OCT)生物标志物,探讨近视改变对糖尿病视网膜病变(DR)进展的影响。方法:本观察性横断面研究回顾性回顾了屈光参差患者的临床记录,包括DR. ETDRS分级评分和OCT生物标志物,包括中央亚场厚度(CST)、中央凹下脉络膜厚度(SFCT)、视网膜下液(SRF)的存在、外核层(ONL)和内核层(INL)的囊样变化、高反射灶(HRF)、椭球区(EZ)连续性、外限制膜(ELM)的连续性、观察低、高屈光度眼视网膜内层组织紊乱及玻璃体黄斑界面变化。研究了双眼球面等效折射(SER)、SFCT和ETDRS评分差异之间的相关性。结果:低屈光度眼的ETDRS评分明显低于高屈光度眼(35.3±14.5比54.4±21.3,P < 0.001), SFCT较薄(153.0±109.4 μm比235.6±107.2 μm, P < 0.001)。低屈光度的眼睛在ONL中表现出更少的囊样空间,HRF降低,DRIL减少,EZ破坏更少。SER和ETDRS评分的双眼差异呈显著正相关(ρ = 0)。789, P < 0.001), SFCT和ETDRS评分(ρ = 0。726, P < 0.001), SER和SFCT (ρ = 0。719, p < 0.001)。结论:较低的ETDRS评分和有利的OCT生物标志物表明,近视似乎对屈光参差的DR进展具有保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.70
自引率
9.10%
发文量
554
审稿时长
3-6 weeks
期刊介绍: ​RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.
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