Survey of prevalence of BKV and JCV infections in pediatric heart transplant recipients

IF 1.4 4区医学 Q4 IMMUNOLOGY

Transplant immunology Pub Date : 2025-05-19 DOI:10.1016/j.trim.2025.102243

Fatemeh Gabeleh , Mohammad Mahdavi , Mohammad Hadi Karbalaie Niya , Mehri Amiri , Mehrdad Ravanshad

{"title":"Survey of prevalence of BKV and JCV infections in pediatric heart transplant recipients","authors":"Fatemeh Gabeleh , Mohammad Mahdavi , Mohammad Hadi Karbalaie Niya , Mehri Amiri , Mehrdad Ravanshad","doi":"10.1016/j.trim.2025.102243","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The Administration of anti-rejection medications in solid organ recipients may increase the risk of acquiring multiple infections. This study aimed to diagnose and monitor BKV and JCV viral infections in pediatric heart transplant recipients.</div></div><div><h3>Methods</h3><div>A cohort of 28 children, all under 18 years old, undergoing heart transplants was studied. Plasma and urine samples were collected, followed by DNA extraction and molecular testing to quantify viral loads. Demographic and clinical information were recorded and analyzed.</div></div><div><h3>Results</h3><div>The BK and JC viruria frequency among the cohort was 41.7 % and 12.5 %, respectively. No instances of BKV and JCV viremia were detected. The BKV DNA viral loads ranged from 3.1 × 10<sup>2</sup> to 11.8 × 10<sup>6</sup> copies/mL, while the JC viruria viral load ranged from 1.1 × 10<sup>2</sup> to 13.6 × 10<sup>6</sup> copies/mL. BKV-JCV co-infection was identified in 12.5 % of patients.</div></div><div><h3>Conclusions</h3><div>Considering a high prevalence of BKV viruria in the recruited patients, clinicians should be well acquainted with the steps involved in the diagnosis and management of polyomaviral infections.</div></div>","PeriodicalId":23304,"journal":{"name":"Transplant immunology","volume":"91 ","pages":"Article 102243"},"PeriodicalIF":1.4000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transplant immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0966327425000711","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

The Administration of anti-rejection medications in solid organ recipients may increase the risk of acquiring multiple infections. This study aimed to diagnose and monitor BKV and JCV viral infections in pediatric heart transplant recipients.

Methods

A cohort of 28 children, all under 18 years old, undergoing heart transplants was studied. Plasma and urine samples were collected, followed by DNA extraction and molecular testing to quantify viral loads. Demographic and clinical information were recorded and analyzed.

Results

The BK and JC viruria frequency among the cohort was 41.7 % and 12.5 %, respectively. No instances of BKV and JCV viremia were detected. The BKV DNA viral loads ranged from 3.1 × 10² to 11.8 × 10⁶ copies/mL, while the JC viruria viral load ranged from 1.1 × 10² to 13.6 × 10⁶ copies/mL. BKV-JCV co-infection was identified in 12.5 % of patients.

Conclusions

Considering a high prevalence of BKV viruria in the recruited patients, clinicians should be well acquainted with the steps involved in the diagnosis and management of polyomaviral infections.

查看原文本刊更多论文

小儿心脏移植受者BKV和JCV感染流行情况调查

背景：在实体器官受者中使用抗排斥药物可能会增加多重感染的风险。本研究旨在诊断和监测小儿心脏移植受者的BKV和JCV病毒感染。方法：对28例接受心脏移植的儿童进行队列研究，年龄均在18岁以下 。收集血浆和尿液样本，随后进行DNA提取和分子检测以量化病毒载量。记录和分析人口统计学和临床信息。结果：队列中BK和JC病毒频率分别为41.7% %和12. %。未发现BKV和JCV病毒血症病例。BKV DNA病毒载量范围为3.1 × 102 ~ 11.8 × 106 copies/mL，而JC病毒载量范围为1.1 × 102 ~ 13.6 × 106 copies/mL。在12. %的患者中发现BKV-JCV合并感染。结论：考虑到BKV病毒在招募患者中的高流行率，临床医生应熟悉多瘤病毒感染的诊断和管理步骤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Transplant immunology 医学-免疫学

CiteScore

2.10

自引率

13.30%

发文量

198

审稿时长

48 days

期刊介绍： Transplant Immunology will publish up-to-date information on all aspects of the broad field it encompasses. The journal will be directed at (basic) scientists, tissue typers, transplant physicians and surgeons, and research and data on all immunological aspects of organ-, tissue- and (haematopoietic) stem cell transplantation are of potential interest to the readers of Transplant Immunology. Original papers, Review articles and Hypotheses will be considered for publication and submitted manuscripts will be rapidly peer-reviewed and published. They will be judged on the basis of scientific merit, originality, timeliness and quality.