Inhibition of the nucleolar RNA exosome facilitates adaptation to starvation.

IF 9.8 1区 生物学 Q1 Agricultural and Biological Sciences
Xi Feng, Xiaoman Wang, Shouhong Guang, Shanshan Pang, Haiqing Tang
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引用次数: 0

Abstract

In response to nutrient scarcity, cells must reallocate their limited energy for cellular maintenance at the expense of certain processes. How such a tradeoff is achieved remains largely unknown. RNA surveillance is crucial for the integrity of the transcriptome, whose defects are associated with several human diseases. Unexpectedly, we discover that the nucleolar RNA exosome, a key RNA surveillance machine, is inhibited by starvation. This is not merely the cessation of a temporarily non-essential process, but rather a key signal to allocate energy. By rewiring one-carbon metabolism, the inhibition of RNA exosome reduces translation, the most energy-consuming process. Energy is then conserved for fat synthesis to enhance cellular maintenance and starvation survival. Notably, while benefiting starvation fitness, RNA exosome inhibition impairs the life span of well-fed animals, indicating a tradeoff between short-term and long-term fitness. Our findings suggest that the nucleolar RNA surveillance can be temporarily sacrificed to facilitate starvation adaptation.

抑制核仁RNA外泌体有助于适应饥饿。
为了应对营养匮乏,细胞必须重新分配有限的能量,以牺牲某些过程来维持细胞。这种权衡是如何实现的在很大程度上仍然未知。RNA监测对转录组的完整性至关重要,转录组的缺陷与几种人类疾病有关。出乎意料的是,我们发现核仁RNA外泌体,一个关键的RNA监视机器,被饥饿抑制。这不仅仅是一个暂时的非必要过程的停止,而是一个分配能量的关键信号。通过重新连接单碳代谢,RNA外泌体的抑制减少了翻译,这是最消耗能量的过程。然后储存能量用于脂肪合成,以增强细胞的维持和饥饿存活。值得注意的是,RNA外泌体抑制虽然有利于饥饿适应度,但会损害营养充足动物的寿命,这表明短期和长期适应度之间存在权衡。我们的研究结果表明,核仁RNA监视可以暂时牺牲,以促进饥饿适应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
PLoS Biology
PLoS Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOLOGY
CiteScore
15.40
自引率
2.00%
发文量
359
审稿时长
3-8 weeks
期刊介绍: PLOS Biology is the flagship journal of the Public Library of Science (PLOS) and focuses on publishing groundbreaking and relevant research in all areas of biological science. The journal features works at various scales, ranging from molecules to ecosystems, and also encourages interdisciplinary studies. PLOS Biology publishes articles that demonstrate exceptional significance, originality, and relevance, with a high standard of scientific rigor in methodology, reporting, and conclusions. The journal aims to advance science and serve the research community by transforming research communication to align with the research process. It offers evolving article types and policies that empower authors to share the complete story behind their scientific findings with a diverse global audience of researchers, educators, policymakers, patient advocacy groups, and the general public. PLOS Biology, along with other PLOS journals, is widely indexed by major services such as Crossref, Dimensions, DOAJ, Google Scholar, PubMed, PubMed Central, Scopus, and Web of Science. Additionally, PLOS Biology is indexed by various other services including AGRICOLA, Biological Abstracts, BIOSYS Previews, CABI CAB Abstracts, CABI Global Health, CAPES, CAS, CNKI, Embase, Journal Guide, MEDLINE, and Zoological Record, ensuring that the research content is easily accessible and discoverable by a wide range of audiences.
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