Association between cardiometabolic index and postmenopausal stress urinary incontinence: a cross-sectional study from NHANES 2013 to 2018.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-05-21 DOI:10.1186/s12944-025-02601-x

Ting Yin, Yue He, Huifang Cong

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引用次数: 0

Abstract

Background: Stress urinary incontinence (SUI) is a common condition affecting the genitourinary system in postmenopausal women. Obesity and dyslipidemia are recognized as significant factors that contribute to the onset of SUI. The cardiometabolic index (CMI), a reliable indicator of health risks associated with obesity, is crucial in assessing these risks. This study aims to investigate the relationship between CMI and the occurrence of SUI in postmenopausal women across the United States.

Methods: This cross-sectional study employed data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2018, concentrating on postmenopausal women aged 40 years and above in the United States. Multiple regression models were utilized to evaluate the association between CMI and postmenopausal SUI, while controlling for pertinent confounding variables. Smooth curve fitting (SCF) techniques were utilized to evaluate the correlation between postmenopausal SUI incidence and CMI. To enhance the robustness of the findings, analyses of subgroups and assessments of interactions were performed.

Results: 542 postmenopausal women participated in the study, with 237 of them indicating the presence of symptoms associated with stress urinary incontinence. The findings from the multiple regression analysis consistently demonstrated a positive correlation between CMI and SUI in all adjusted models. In particular, a one-unit increase in CMI correlated with a 63% greater probability of encountering postmenopausal SUI in fully adjusted models (OR = 1.63, 95% CI: 1.07-2.48). Additionally, a direct correlation was noted between CMI levels and the occurrence of SUI within this population. Subgroup analysis by the number of vaginal deliveries showed a significant interaction (P for interaction = 0.0471).

Conclusions: The findings emphasize the importance of managing CMI levels to identify postmenopausal women at increased risk for SUI. This study confirms the strong predictive value of CMI for SUI in this population.

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心脏代谢指数与绝经后应激性尿失禁之间的关系：NHANES 2013 - 2018的横断面研究

背景：应激性尿失禁（SUI）是影响绝经后妇女泌尿生殖系统的常见疾病。肥胖和血脂异常被认为是SUI发病的重要因素。心脏代谢指数（CMI）是与肥胖相关的健康风险的可靠指标，对评估这些风险至关重要。本研究旨在探讨美国绝经后妇女CMI与SUI发生的关系。方法：本横断面研究采用了2013年至2018年进行的国家健康与营养检查调查（NHANES）的数据，重点关注美国40岁及以上的绝经后妇女。在控制相关混杂变量的情况下，采用多元回归模型评估CMI与绝经后SUI之间的关系。采用平滑曲线拟合（SCF）技术评估绝经后SUI发生率与CMI的相关性。为了增强研究结果的稳健性，进行了亚组分析和相互作用评估。结果：542名绝经后妇女参与了这项研究，其中237人显示存在与压力性尿失禁相关的症状。多元回归分析的结果一致表明，在所有调整后的模型中，CMI与SUI呈正相关。特别是，在完全调整的模型中，CMI每增加一个单位，绝经后SUI发生的概率增加63% （OR = 1.63, 95% CI: 1.07-2.48）。此外，在该人群中，CMI水平与SUI发生之间存在直接相关性。阴道分娩次数的亚组分析显示有显著的相互作用（相互作用P = 0.0471）。结论：研究结果强调了管理CMI水平对于识别绝经后SUI风险增加的妇女的重要性。本研究证实了CMI对该人群SUI的强大预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.