Cerebellar grey matter volume predicts cerebellar tDCS efficacy in individuals with Friedreich ataxia.

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2025-05-16 DOI:10.1016/j.clinph.2025.2110744

Gilles Naeije, Christian Georgiev, Pierre Cabaraux, Mathieu Bourguignon

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引用次数: 0

Abstract

Objective: To determine the impact of cerebellar anatomy on ctDCS efficacy in individuals with Friedreich ataxia (FA).

Methods: We included 24 FA patients (mean age 31 ± 14 years) and 24 age- and sex-matched healthy controls. Patients underwent a 5-day ctDCS intervention, with cerebellar motor and non-motor symptoms assessed using the Scale for the Assessment and Rating of Ataxia (SARA) and the Cerebellar Cognitive Affective Syndrome Scale (CCAS-S), before and after stimulation. MRI was used to measure cerebellar gray matter volume, superior cerebellar peduncle (SCP) diameter, and skin-to-cerebellum distance. Stepwise linear regression analyses examined predictors of motor and cognitive improvements following ctDCS.

Results: FA patients exhibited significantly reduced cerebellar gray matter volume compared to controls (p = 0.024) after intracranial volume correction, skin-to-cerebellum distance did not differ between groups (p = 0.11). Stepwise linear regression analysis disclosed that the anterior cerebellar gray matter volume was a significant predictor of SARA improvement (β = -0.18, p < 0.001) and the posterior cerebellar gray matter volume of CCAS-S improvement (β = -0.13, p 0.023). Neither SCP diameter nor skin-to-cerebellum distance significantly impacted ctDCS efficacy.

Conclusion: Cerebellar gray matter volume is associated to ctDCS-induced symptoms improvements in FA.

Significance: These findings suggest that cerebellar gray matter volume influences ctDCS responsiveness.

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小脑灰质体积可预测弗里德赖希共济失调患者小脑tDCS的疗效。

目的：探讨小脑解剖对弗里德赖希共济失调（FA）患者ctDCS疗效的影响。方法：我们纳入24例FA患者（平均年龄31±14岁）和24例年龄和性别匹配的健康对照。患者接受为期5天的ctDCS干预，在刺激前后分别使用共济失调评估和评定量表（SARA）和小脑认知情感综合征量表（CCAS-S）评估小脑运动和非运动症状。MRI测量小脑灰质体积、小脑上脚直径、皮肤到小脑的距离。逐步线性回归分析检验了ctDCS后运动和认知改善的预测因子。结果：FA患者颅内体积矫正后，小脑灰质体积较对照组明显减少（p = 0.024），两组间皮肤到小脑的距离无差异（p = 0.11）。逐步线性回归分析显示，小脑前部灰质体积是SARA改善的显著预测因子（β = -0.18, p）。结论：小脑灰质体积与ctdcs诱导的FA症状改善有关。意义：这些发现提示小脑灰质体积影响ctDCS的反应性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.