Influence of Bifurcation Morphology on Exercise-Induced PAH Deposition in the Lungs: A Computational Modeling Approach for Air Quality Research.

IF 3 3区医学 Q2 BIOPHYSICS

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-05-21 DOI:10.1007/s10237-025-01968-1

Justus Kavita Mutuku, Hsin-Chieh Kung, Wei-Hsin Chen, Chien-Er Huang, Kuan Shiong Khoo, Pau Loke Show

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Abstract

This study examines the influence of lung geometry, physical activity intensity, and aerosol concentration on the deposition efficiencies (DEs) of particulate matter with surface-bound polycyclic aromatic hydrocarbons (PM-_PAHs) in human lung generations 3-6. Two-phase flows were effected in ANSYS 2020R2 platform using planar and orthogonal lung geometries, with two levels of physical activities, 4 metabolic equivalents (4 METs), and 8 METs. Aerosol concentrations of 0.95 μg‧m^-3, 1.57 μg‧m^-3, and 2.04 μg‧m^-3 represent rural, urban, and industrial areas, respectively. Relative differences in DEs for 1 μm, 3.2 μm, and 5.6 μm exhibit variations between the two geometries with ranges of 0%-84.4% for 4 METs and 1.2%-50.7% for 8 METs. The first carina region was the most significant hotspot for the 5.6 μm particles. On the other hand, the 1 μm and 3.2 μm aerosols infiltrated and deposited evenly at the lower sections of the lungs. Regarding PM-_PAHs doses, spatial variations indicate an industrial > urban > rural hierarchy. This investigation suggests that individuals in industrial and urban locations should manage the intensity of their outdoor activities to minimize exposure to PM-_PAHs. These findings are instrumental for public health interventions aimed at reducing exposure to PM-_PAHs and preventing associated health problems.

查看原文本刊更多论文

分岔形态对运动诱导的肺内多环芳烃沉积的影响：空气质量研究的计算建模方法。

本研究考察了肺部几何形状、身体活动强度和气溶胶浓度对3-6代人肺部表面结合多环芳烃（PM-PAHs）颗粒物沉积效率（DEs）的影响。在ANSYS 2020R2平台上，采用平面和正交肺几何形状，在两个水平的身体活动，4个代谢当量（4 METs）和8个METs下实现两相流动。气溶胶浓度分别为0.95 μg·m-3、1.57 μg·m-3和2.04 μg·m-3，分别代表农村、城市和工业地区。1 μm、3.2 μm和5.6 μm的相对DEs差异在两种几何形状之间表现出差异，4个METs的差异范围为0%-84.4%，8个METs的差异范围为1.2%-50.7%。对于5.6 μm的粒子，第一底端区域是最显著的热点。另一方面，1 μm和3.2 μm气溶胶在肺下部均匀浸润和沉积。关于多环芳烃的剂量，空间变化表明工业b>城市b>农村等级。这项调查表明，工业和城市地区的个人应管理其户外活动的强度，以尽量减少暴露于多环芳烃。这些发现有助于开展旨在减少多环芳烃暴露和预防相关健康问题的公共卫生干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomechanics and Modeling in Mechanobiology 工程技术-工程：生物医学

CiteScore

7.10

自引率

8.60%

发文量

119

审稿时长

6 months

期刊介绍： Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that (1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury, (2) identify and quantify mechanosensitive responses and their mechanisms, (3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and (4) report discoveries that advance therapeutic and diagnostic procedures. Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.