Recent Advances in the Photochemical Biology of Serotonin.

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2025-05-21 DOI:10.1002/cbic.202500276

Claire E Nieder, Michael A Kienzler

引用次数: 0

Abstract

Serotonin (5-HT) is an endogenous neurotransmitter that plays a key role in cellular signaling. Its interactions with serotonin receptors (5-HTRs) and the serotonin transporter (SERT) influence processes as disparate as hunger, happiness, healing, and headaches. Over the last several decades, photochemical tools have been developed to observe, track, and modulate these serotonin-protein interactions. The tools tend to fit into one of four categories: photoswitches, photocages, photobiosensors, or photocross-linkers. This review examines the development and application of these photochemical tools for 5-HT, 5-HTRs, and SERT over the last ≈10 years, with an emphasis on the chemistry involved.

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血清素光化学生物学研究进展。

5-羟色胺（5-HT）是一种内源性神经递质，在细胞信号传导中起关键作用。它与5-羟色胺受体（5-HTRs）和5-羟色胺转运体（SERT）的相互作用影响着不同的过程，如饥饿、快乐、愈合和头痛。在过去的几十年里，光化学工具已经发展到观察、跟踪和调节这些血清素-蛋白质的相互作用。这些工具通常可以分为四类：光开关、光笼、光生物传感器或光交联剂。本文综述了近10年来5-HT、5- hts和SERT光化学工具的发展和应用，重点介绍了其中的化学成分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).