Multi-doped glasses with Mg²⁺ and Zn²⁺ ions in glass-ionomer cements.

IF 4.6 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Dental Materials Pub Date : 2025-05-20 DOI:10.1016/j.dental.2025.04.009

John Makanjuola, Robert Hill, Sadia Niazi, Joseph Aduse-Opoku, Neelam Gurav, Subir Banerji, Sanjukta Deb

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引用次数: 0

Abstract

Objective: To develop a new, biocompatible glass-ionomer cement (GIC) with improved antibacterial activity and physical properties through multiple ionic substitutions of strontium with magnesium and zinc.

Methods: A fluoro-alumino-silicate glass (LG99Sr) with composition 4.5SiO₂-3Al₂O₃-1.5 P₂O₅-3SrF₂-2SrO was synthesized using the melt-quench technique. LG99Sr was modified by partially substituting SrO with MgO and ZnO, yielding a new composition 4.5SiO₂-3Al₂O₃-1.5 P₂O₅-3SrF₂-0.5SrO-1MgO-0.5ZnO (LG99Sr-Mg-Zn). Following glass characterization, GICs were prepared using Fuji IX (GC Corporation, Tokyo, Japan) as a reference. Physical properties, antimicrobial activity (against Streptococcus mutans, Streptococcus mitis/oralis, and Lactobacillus paracasei), and in vitro cytocompatibility were evaluated. Data were analysed using two-way ANOVA and Tukey-Kramer HSD post-hoc tests to determine the differences in properties between groups (p < 0.05).

Results: The presence of magnesium and zinc in LG99Sr-Mg-Zn was validated via EDS analysis, with ICP-MS confirming their release upon immersion. All GICs demonstrated similar fluoride release profiles; notably, LG99Sr-Mg-Zn exhibited a higher initial fluoride release. Mechanical properties at 24 hours were comparable; however, LG99Sr-Mg-Zn and Fuji IX showed significant improvements (p < 0.05) post-maturation compared to LG99Sr. After 1-month maturation, compressive strength, flexural strength, and Vickers microhardness were significantly higher (p < 0.05) for Fuji IX and LG99Sr-Mg-Zn, and microhardness remained significantly higher at 90 days. Agar diffusion, biofilm inhibition, and XTT tests revealed enhanced antibacterial activity (p < 0.05) for LG99Sr-Mg-Zn. MTT and alamarBlue assays confirmed zinc concentration in LG99Sr-Mg-Zn was not cytotoxic.

Significance: Ionic substitution of magnesium and zinc in fluoro-alumino-silicate glass significantly enhanced fluoride release and antibacterial properties, improved mechanical properties upon maturation, and maintained cell viability, making it a promising restorative material.

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Mg2+和Zn2+离子在玻璃离子聚合物水泥中的多掺杂玻璃。

目的：通过镁、锌等多种离子取代锶，制备一种具有生物相容性的新型玻璃离子水泥（GIC），提高其抗菌活性和物理性能。方法：采用熔融淬火技术合成了成分为4.5SiO₂-3Al₂O₃-1.5 P₂O₅-3SrF₂-2SrO的氟铝硅酸盐玻璃（LG99Sr）。通过用MgO和ZnO部分取代SrO对LG99Sr进行改性，得到新的组合物4.5SiO₂-3Al₂O₃-1.5 P₂O₅-3SrF₂-0.5SrO-1MgO-0.5ZnO （LG99Sr- mg - zn）。在玻璃化表征之后，以Fuji IX （GC Corporation, Tokyo, Japan）为基准制备了gic。对其物理特性、抗菌活性（抗变形链球菌、口腔炎链球菌和副干酪乳杆菌）和体外细胞相容性进行了评价。采用双向方差分析和Tukey-Kramer HSD事后检验对数据进行分析，以确定组间性质的差异（p ）结果：通过EDS分析验证了LG99Sr-Mg-Zn中镁和锌的存在，并通过ICP-MS确认其在浸泡后释放。所有gic都显示出类似的氟化物释放概况；值得注意的是，LG99Sr-Mg-Zn表现出更高的初始氟释放量。24 小时的力学性能具有可比性；但LG99Sr-Mg-Zn和Fuji IX表现出了显著的改善（p ）意义：氟铝硅酸盐玻璃中镁和锌的离子取代显著增强了氟的释放和抗菌性能，提高了成熟后的力学性能，并保持了细胞活力，使其成为一种有前景的修复材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dental Materials 工程技术-材料科学：生物材料

CiteScore

9.80

自引率

10.00%

发文量

290

审稿时长

67 days

期刊介绍： Dental Materials publishes original research, review articles, and short communications. Academy of Dental Materials members click here to register for free access to Dental Materials online. The principal aim of Dental Materials is to promote rapid communication of scientific information between academia, industry, and the dental practitioner. Original Manuscripts on clinical and laboratory research of basic and applied character which focus on the properties or performance of dental materials or the reaction of host tissues to materials are given priority publication. Other acceptable topics include application technology in clinical dentistry and dental laboratory technology. Comprehensive reviews and editorial commentaries on pertinent subjects will be considered.