Long-term alcohol consumption and incident health risk conditions related to cardiometabolic risk markers: A 20-year prospective cohort study.

IF 5.2 1区医学 Q1 PSYCHIATRY

Addiction Pub Date : 2025-05-21 DOI:10.1111/add.70092

Sooyeun Choi, Taeyoung Park, Youjin Je

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引用次数: 0

Abstract

Background and aims: Amid questions about a perceived association between low-to-moderate alcohol consumption and reduced cardiovascular risk from recent studies, research examining the impact of alcohol consumption on cardiometabolic risk markers has reported inconsistent results. We measured the association between long-term alcohol consumption and incident health risk conditions related to cardiometabolic risk markers.

Design, setting and participants: A prospective cohort analysis was conducted using data from a population-based cohort (2001-2020) of 4708 Koreans aged 40-69 years who were free of chronic diseases, including metabolic syndrome, at baseline.

Measurements: Alcohol consumption and incident cases related to cardiometabolic risk markers were assessed biennially using interviewer-administered questionnaires or health examinations. The average alcohol intake was calculated to reflect long-term consumption. Alcohol consumption was categorized as none or rarely (0-2 g/day), light (2 < -16 g/day, within guideline limits), medium (16 < -32 g/day) and heavy (>32 g/day).

Findings: After full adjustment for covariates, light, medium or heavy alcohol consumption was positively associated with metabolic syndrome [hazard ratio (HR) = 1.55, 95% confidence interval (CI) = 1.32-1.83], abdominal obesity (HR = 1.41, 95% CI = 1.17-1.70), hyperglycemia (HR = 1.91, 95% CI = 1.62-2.26), high blood pressure (HR = 2.04, 95% CI = 1.72-2.41) and hypertriglyceridemia (HR = 1.59, 95% CI = 1.30-1.93), with the results presented for heavy alcohol consumption only (p-values for trend <0.001 for all cases). By sex, positive associations between light alcohol intake and hyperglycemia and high blood pressure were observed only in women (p-values for interaction and p-values for trend <0.05 for all cases).

Conclusions: Long-term light (within guideline limits), medium or heavy alcohol consumption appears to be positively and linearly associated with incident health risk conditions related to cardiometabolic risk markers. The threshold dose of alcohol for developing hyperglycemia and high blood pressure appears to be lower in women.

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长期饮酒与心血管代谢风险标志物相关的突发健康风险状况：一项20年前瞻性队列研究

背景和目的：在最近的研究中，人们对低至中度饮酒与降低心血管风险之间的关联存在疑问，研究酒精消费对心血管代谢风险标志物的影响的研究报告了不一致的结果。我们测量了长期饮酒与与心脏代谢风险标志物相关的突发健康风险状况之间的关联。设计、环境和参与者：使用基于人群的队列（2001-2020）的数据进行前瞻性队列分析，4708名年龄在40-69岁之间的韩国人在基线时无慢性疾病，包括代谢综合征。测量方法：每两年对饮酒和与心脏代谢风险标志物相关的事件进行评估，采用访谈者管理的问卷或健康检查。平均酒精摄入量的计算反映了长期消费量。酒精消费分为无或很少（0-2克/天）、少量（2 32克/天）。发现:在对协变量进行完全调整后，轻度、中度或重度饮酒与代谢综合征(风险比（HR) = 1.55, 95%可信区间(CI) = 1.32-1.83）、腹部肥胖（HR = 1.41, 95% CI = 1.17-1.70）、高血糖（HR = 1.91, 95% CI = 1.62-2.26）、高血压（HR = 2.04, 95% CI = 1.72-2.41）和高甘油三酯血症（HR = 1.59, 95% CI = 1.30-1.93）呈正相关。结论：长期轻度（在指南限制范围内）、中度或重度饮酒似乎与与心脏代谢风险标志物相关的突发健康风险状况呈正相关和线性相关。女性患高血糖和高血压的酒精阈值似乎较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Addiction 医学-精神病学

CiteScore

10.80

自引率

6.70%

发文量

319

审稿时长

3 months

期刊介绍： Addiction publishes peer-reviewed research reports on pharmacological and behavioural addictions, bringing together research conducted within many different disciplines. Its goal is to serve international and interdisciplinary scientific and clinical communication, to strengthen links between science and policy, and to stimulate and enhance the quality of debate. We seek submissions that are not only technically competent but are also original and contain information or ideas of fresh interest to our international readership. We seek to serve low- and middle-income (LAMI) countries as well as more economically developed countries. Addiction’s scope spans human experimental, epidemiological, social science, historical, clinical and policy research relating to addiction, primarily but not exclusively in the areas of psychoactive substance use and/or gambling. In addition to original research, the journal features editorials, commentaries, reviews, letters, and book reviews.