Biocomposites-Coated Biodegradable Materials with Optimized Properties for Orthopedic Implant Biodegradability and Performance: A Comparative Study.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Hari Raj K, Gnanavel Sadasivam, Vamsi Krishna Dommeti
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引用次数: 0

Abstract

Implant failure continues to be a critical concern in orthopedic interventions, frequently resulting in consequences such as fractures and necessitating revision procedures. Multiple causes, such as mechanical failure, inadequate osteointegration, and corrosion, lead to implant failure over time. This study seeks to resolve these challenges by surface-modifying biodegradable materials such as poly(lactic acid) (PLA) and AZ31 Mg alloy (Mg), integrating novel Biocomposites of titanium-hydroxyapatite (Ti-HA) to improve their efficacy. The altered materials aim to enhance mechanical strength, osteointegration, and regulated deterioration, thus minimizing the likelihood of implant failure. The characterization techniques validated the Biocomposites' adhesion on the implant's surface, mechanical analysis and corrosion resistance were also validated with the help of UTS and electrochemical studies, and in vitro analyses exhibited substantial improvements in material durability and biological compatibility. The result shows that the Biocomposite assistance improved the overall performance of the implant material. This work presents a pioneering strategy to mitigate implant failure by emphasizing these enhancements, facilitating more dependable and efficient solutions in orthopedic implantation, ultimately enhancing patient outcomes and decreasing the necessity for revision procedures. The earlier segment of the research study was confirmed with another Biocomposites (Ti-Zr), representing a continuation of that research work.

生物复合涂层生物可降解材料与骨科植入物生物降解性能的比较研究。
植入物失败仍然是骨科干预的一个关键问题,经常导致骨折和需要翻修手术等后果。随着时间的推移,机械故障、骨整合不足和腐蚀等多种原因会导致种植体失效。本研究旨在通过表面改性生物可降解材料,如聚乳酸(PLA)和AZ31镁合金(Mg),整合新型钛-羟基磷灰石(Ti-HA)生物复合材料来提高其功效,从而解决这些挑战。改变的材料旨在提高机械强度,骨整合和调节退化,从而最大限度地减少种植体失败的可能性。表征技术验证了生物复合材料在植入物表面的粘附性,力学分析和耐腐蚀性也在UTS和电化学研究的帮助下得到了验证,体外分析显示材料耐久性和生物相容性有了实质性的改善。结果表明,生物复合材料辅助材料提高了种植材料的整体性能。这项工作提出了一个开创性的策略,通过强调这些增强来减轻植入失败,促进更可靠和有效的骨科植入解决方案,最终提高患者的治疗效果,减少翻修手术的必要性。研究的早期部分得到了另一种生物复合材料(Ti-Zr)的证实,代表了该研究工作的继续。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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