Association of Dietary Index for Gut Microbiota With Hyperuricemia in Adults: A Cross-Sectional Study of NHANES 2007–2018

Abstract

Objective

To detect the potential association between the dietary index for gut microbiota (DI-GM) and hyperuricemia.

Method

Utilizing cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) data, a multivariable logistic regression model was employed to reveal the impact of DI-GM on uric acid levels. The results indicate that participants with hyperuricemia had significantly lower DI-GM levels compared to those without hyperuricemia (OR = 0.93, 95% CI: 0.91–0.95, p < 0.001). Furthermore, even after adjusting for covariates, the association between DI-GM and hyperuricemia remained significant (OR = 0.97, 95% CI: 0.95–0.99, p = 0.012), suggesting a risk factor association between high DI-GM and low uric acid levels. The study also revealed a gradual decrease in the risk of hyperuricemia with increasing DI-GM, indicating the potential of DI-GM as a prognostic assessment marker (p for overall < 0.001). Additionally, a weak negative correlation between DI-GM and chronic kidney disease (CKD) was observed among patients with hyperuricemia (Adjusted OR = 0.90, 95% CI: 0.82–0.99, p = 0.027).

Conclusion

These findings support the utility of DI-GM as a potential biomarker with important implications for the prevention and treatment of hyperuricemia. This discovery provides a crucial basis for the development of future dietary interventions and strategies related to gut microbiota, warranting further in-depth research to validate its applicability and effectiveness in diverse populations.