Printabily of Pharmaceutical-Grade Polymers using Selective Laser Sintering with a CO2 Laser

IF 4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Atabak Tabriz, Laura Andrade Junqueira, Siva Satyanarayana Kolipaka, Ho-Wah Hui, Nathan Boersen, Sandra Roberts, John Jones, Dennis Douroumis
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Abstract

Selective laser sintering (SLS) has gained attention for pharmaceutical applications and the printing of solid oral dosage forms. The aim of this study was to evaluate the suitability of various pharmaceutical-grade polymers for tablet production using an SLS printer equipped with a CO2 laser. Seven polymers, offering a range of release profiles such as immediate, controlled, and pH-dependent, were selected for investigation. Initially, the materials were characterized, revealing significant variations in their properties, including glass transition temperature, degradation temperature, mean particle size, and flowability. While some polymers exhibited ideal properties for printing, others were less suitable. By varying printing parameters such as the laser power, bed temperature, scanning speed, and powder feed rate, all powders were used for the reproducible fabrication of tablets. The physical properties of the tablets, including the hardness and friability, as well as their microstructure were affected by both the polymer grade and the laser intensity. The tablet physical characteristics varied according to the used polymer and thus hardness values ranged from 31 to 350 N, while friability varied across different formulations, with few tablets exhibiting values below 1%, others between 1–3%, and some exceeding 5%. Overall, this work demonstrated the suitability of using various pharmaceutical-grade polymers to produce tablets using SLS with a CO2 laser.

Graphical Abstract

用CO2激光器选择性激光烧结制备医药级聚合物的可印刷性
选择性激光烧结(SLS)在制药和固体口服剂型印刷方面的应用越来越受到关注。本研究的目的是利用配备CO2激光器的SLS打印机评估各种药物级聚合物用于片剂生产的适用性。研究人员选择了7种聚合物,它们提供了一系列的释放特性,如即时释放、受控释放和ph依赖性释放。首先,对材料进行了表征,揭示了其性能的显著变化,包括玻璃化转变温度、降解温度、平均粒径和流动性。虽然一些聚合物表现出理想的打印性能,但其他聚合物则不太合适。通过改变激光功率、床层温度、扫描速度和粉末进料速度等印刷参数,所有粉末均可用于片剂的重复性制备。聚合物等级和激光强度对片剂的硬度、脆性等物理性能及微观结构均有影响。根据所用聚合物的不同,片剂的物理特性也有所不同,因此硬度值从31到350 N不等,而不同配方的片剂的脆度也不同,很少片剂的脆度低于1%,有些片剂的脆度在1-3%之间,有些片剂的脆度超过5%。总的来说,这项工作证明了使用SLS与CO2激光器使用各种药物级聚合物生产片剂的适用性。图形抽象
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来源期刊
AAPS PharmSciTech
AAPS PharmSciTech 医学-药学
CiteScore
6.80
自引率
3.00%
发文量
264
审稿时长
2.4 months
期刊介绍: AAPS PharmSciTech is a peer-reviewed, online-only journal committed to serving those pharmaceutical scientists and engineers interested in the research, development, and evaluation of pharmaceutical dosage forms and delivery systems, including drugs derived from biotechnology and the manufacturing science pertaining to the commercialization of such dosage forms. Because of its electronic nature, AAPS PharmSciTech aspires to utilize evolving electronic technology to enable faster and diverse mechanisms of information delivery to its readership. Submission of uninvited expert reviews and research articles are welcomed.
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