Health risks and toxicity mechanisms of medicinal and aromatic plants (MAPs): A comprehensive review of adverse effects on organ systems, genotoxicity and reproductive toxicity

Abstract

The use of medicinal and aromatic plants (MAPs) requires careful evaluation due to their potential effects on human health. Assessing the risks, including toxicity and adverse effects, is essential to ensure their safe application. Our bibliometric analysis revealed a high prevalence of research focusing on MAPs' health impacts, with frequent mentions of “side effects” and “toxicity,” emphasizing the need for further investigation into their active ingredients and mechanisms of action. The potential health effects of MAPs have been documented across various organ systems, including gastrointestinal (vomiting and diarrhea), renal (nephrotoxicity), hepatic (hepatotoxicity), and neurological (neurotoxicity). These effects arise from interactions between plant compounds and metabolic enzymes, cellular receptors, and signaling pathways, potentially leading to toxicity. The mechanisms discussed include oxidative stress, mitochondrial dysfunction, inhibition of metabolic enzymes, DNA damage (genotoxicity), and endocrine disruption, which may explain the diverse observed toxicological profiles. This review highlights the complex relationship between botanical substances and human health, integrating current applications while raising awareness of associated risks. It also underscores the importance of strict regulations and responsible use to ensure the safe and effective integration of MAPs into healthcare practices.