New secondary metabolites from the soil-derived Aspergillus versicolor QC812

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Steroids Pub Date : 2025-05-19 DOI:10.1016/j.steroids.2025.109629

Jiacheng Weng , Siqi Li , Runchao Ma, Qi Shi, Xiongyu Meng, Guifen Zhou, Luping Qin, Huaqiang Li

引用次数: 0

Abstract

A new 18,22-cyclosterol, aspersteroline A (1), and a new DMOA-derived meroterpenoid, asperterpene O (2), along with three known compounds (3 − 5), namely mer-NF8054X (3), terretonin D (4), and asperterpene J (5), were isolated from the soil-derived Aspergillus versicolor QC812. The structures of new compounds were established based on widespread spectrographic methods, mainly including 1D & 2D NMR and HRESIMS analyses, and the absolute configurations were further confirmed by comparison of calculated and experimental electronic circular dichroism (ECD) curves. The cytotoxicity of isolates was evaluated on five human tumor cell lines, 1 and 3 showed moderate cytotoxic activities against HL-60.

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土源杂色曲霉QC812新的次生代谢物

从土壤来源的versicolor Aspergillus QC812中分离得到新的18,22-环甾醇aspersteroline A(1)和新的dmoa衍生的meroterpene asperterpene O(2)，以及三个已知化合物mer-NF8054X(3)、terretonin D(4)和asperterpene J(5)。基于广谱方法建立了新化合物的结构，主要包括1D &；通过计算的电子圆二色性（ECD）曲线和实验的电子圆二色性曲线的比较，进一步证实了其绝对构型。对5株人肿瘤细胞株进行了细胞毒性评价，1和3株对HL-60表现出中等的细胞毒活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Steroids 医学-内分泌学与代谢

CiteScore

5.10

自引率

3.70%

发文量

120

审稿时长

73 days

期刊介绍： STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.