Air pollution and atherosclerosis

IF 5.7 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Atherosclerosis Pub Date : 2025-05-16 DOI:10.1016/j.atherosclerosis.2025.119240

Anusha N. Seneviratne , Mark R. Miller

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Abstract

Air pollution is associated with considerable cardiovascular mortality and morbidity. The vascular disease atherosclerosis underlies many cardiovascular conditions, with atherosclerotic plaque rupture being a trigger for stroke and myocardial infarction. The acute and chronic effects of air pollution have the potential to exacerbate many different facets of atherosclerosis. This review provides an overview of how air pollution promotes the development of atherosclerosis. The review summaries the epidemiological evidence between exposure to air pollution and morphological measures of atherosclerosis such as carotid intimal media thickness, coronary artery calcification and aortic artery calcification, before summarising the biological mechanisms by which air pollution promotes atherosclerosis at the different stages of disease progression. We offer our perspective of the weight of evidence between air pollution to atherosclerosis and make recommendations for future research to advance this field. Given the ubiquity of air pollution exposure, we stress the need for urgency in efforts to tackle air pollution and emphasise the potential health gains from minimising the effects of air pollutants on this common and often fatal cardiovascular pathology.

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空气污染与动脉粥样硬化

空气污染与相当多的心血管疾病死亡率和发病率有关。血管疾病动脉粥样硬化是许多心血管疾病的基础，动脉粥样硬化斑块破裂是中风和心肌梗死的触发因素。空气污染的急性和慢性影响有可能加剧动脉粥样硬化的许多不同方面。本文综述了空气污染如何促进动脉粥样硬化的发展。这篇综述总结了空气污染暴露与动脉粥样硬化形态学指标（如颈动脉内膜中层厚度、冠状动脉钙化和主动脉钙化）之间的流行病学证据，然后总结了空气污染在疾病进展的不同阶段促进动脉粥样硬化的生物学机制。我们对空气污染与动脉粥样硬化之间的证据权重提出了我们的观点，并为未来的研究提出了建议，以推进这一领域的发展。鉴于空气污染暴露无处不在，我们强调迫切需要解决空气污染问题，并强调最大限度地减少空气污染物对这一常见且往往致命的心血管疾病的影响可能带来的健康益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Atherosclerosis 医学-外周血管病

CiteScore

9.80

自引率

3.80%

发文量

1269

审稿时长

36 days

期刊介绍： Atherosclerosis has an open access mirror journal Atherosclerosis: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Atherosclerosis brings together, from all sources, papers concerned with investigation on atherosclerosis, its risk factors and clinical manifestations. Atherosclerosis covers basic and translational, clinical and population research approaches to arterial and vascular biology and disease, as well as their risk factors including: disturbances of lipid and lipoprotein metabolism, diabetes and hypertension, thrombosis, and inflammation. The Editors are interested in original or review papers dealing with the pathogenesis, environmental, genetic and epigenetic basis, diagnosis or treatment of atherosclerosis and related diseases as well as their risk factors.