The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility.

IF 12.8 1区生物学 Q1 CELL BIOLOGY

Protein & Cell Pub Date : 2025-05-22 DOI:10.1093/procel/pwaf043

Xiaoting Hou,Yu Chen,Bo Zhou,Fengting Liu,Lingyun Dai,Chunbo Chen,Noah D Carrillo,Vincent L Cryns,Richard A Anderson,Jichao Sun,Mo Chen

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引用次数: 0

Abstract

Dysregulation of p53 and phosphoinositide (PIPn) signaling are both key drivers of oncogenesis and metastasis. Our recent findings reveal a previously unrecognized interaction between these pathways, converging in the nucleus to form a PIPn-p53 signalosome that modulates nuclear AKT activation and downstream signaling, thereby influencing cancer cell survival and motility. This review examines recent insights into nuclear PIPn signaling in the context of established roles for p53 in cell dynamics and migration while also deliberating current research on how nuclear PIPns interact with p53 to form signalosomes that affect cell motility. We emphasize the critical role of PIPns in stabilizing p53 and activating de novo nuclear AKT signaling, which subsequently modulates key motility-related pathways. Understanding the unique operation and function of the PIPn-p53 signalosome in nuclear phosphatidylinositol 3-kinase (PI3K)-AKT activation offers novel therapeutic strategies for controlling cancer metastasis by targeting pertinent interactions and events.

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核磷酸肌醇-p53信号体在细胞运动调节中的作用。

p53和磷酸肌肽（PIPn）信号的失调都是肿瘤发生和转移的关键驱动因素。我们最近的研究结果揭示了这些途径之间以前未被认识到的相互作用，在细胞核中聚集形成PIPn-p53信号体，调节核AKT激活和下游信号，从而影响癌细胞的存活和运动。这篇综述探讨了在p53在细胞动力学和迁移中已确立的作用的背景下，核PIPn信号传导的最新见解，同时也审议了核PIPn如何与p53相互作用形成影响细胞运动的信号体的当前研究。我们强调PIPns在稳定p53和激活新生核AKT信号中的关键作用，AKT信号随后调节关键的运动相关通路。了解PIPn-p53信号体在核磷脂酰肌醇3-激酶(PI3K)-AKT活化中的独特作用和功能，为通过靶向相关相互作用和事件来控制癌症转移提供了新的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Protein & Cell CELL BIOLOGY-

CiteScore

24.00

自引率

0.90%

发文量

1029

审稿时长

6-12 weeks

期刊介绍： Protein & Cell is a monthly, peer-reviewed, open-access journal focusing on multidisciplinary aspects of biology and biomedicine, with a primary emphasis on protein and cell research. It publishes original research articles, reviews, and commentaries across various fields including biochemistry, biophysics, cell biology, genetics, immunology, microbiology, molecular biology, neuroscience, oncology, protein science, structural biology, and translational medicine. The journal also features content on research policies, funding trends in China, and serves as a platform for academic exchange among life science researchers.