Consumption of Fruit Juice and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.

IF 2.5 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

American Journal of Medicine Pub Date : 2025-05-18 DOI:10.1016/j.amjmed.2025.05.021

Chung-Woo Lee, Seung-Kwon Myung

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引用次数: 0

Abstract

Background: Previous observational studies on the association between the consumption of fruit juice and the risk of type 2 diabetes mellitus have reported inconsistent findings. We investigated the association using a meta-analysis of prospective cohort studies.

Methods: Studies were identified through PubMed and EMBASE searches from inception to August 3, 2024. We calculated pooled relative risks (RRs) and 95% confidence intervals (CIs). The consumption of fruit juice was categorized into 100% fruit juice and non-100% fruit juice. The primary outcome was the incidence of type 2 diabetes mellitus.

Results: Out of 1591 articles, 14 prospective cohort studies were included in the final analysis. In the meta-analysis of all studies, there was no significant association between the consumption of overall fruit juice and the risk of type 2 diabetes mellitus (RR, 1.06 [95% CI, 0.98-1.15], P = .170). In the subgroup meta-analysis by juice type, non-100% fruit juice was statistically significantly associated with an increased risk of type 2 diabetes mellitus (RR, 1.15 [95% CI, 1.03-1.28], P = .012), while there was no significant association between the consumption of 100% fruit juice and the risk of type 2 diabetes mellitus. An increased risk of type 2 diabetes mellitus by fruit juice was observed only in Asian populations (RR, 1.17 [95% CI 1.02-1.34], P = .023).

Conclusion: The consumption of non-100% fruit juice increased the risk of type 2 diabetes mellitus. Unlike whole fruit consumption, 100% fruit juice had no beneficial effect on the risk of type 2 diabetes mellitus.

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饮用果汁与2型糖尿病风险：一项前瞻性队列研究的系统回顾和荟萃分析：果汁与2型糖尿病风险

背景：先前关于果汁饮用与2型糖尿病风险之间关系的观察性研究报告了不一致的结果。我们使用前瞻性队列研究的荟萃分析来调查这种关联。方法：通过PubMed和EMBASE检索从开始到2024年8月3日的研究。我们计算了合并相对危险度（rr）和95%置信区间（ci）。果汁的消耗量分为100%果汁和非100%果汁。主要结局是2型糖尿病的发病率。结果：在1591篇文章中，14篇前瞻性队列研究被纳入最终分析。在所有研究的荟萃分析中，总果汁摄入量与2型糖尿病风险之间没有显著关联（RR, 1.06 [95% CI, 0.98-1.15], P = 0.170）。在按果汁类型进行的亚组荟萃分析中，非100%果汁与2型糖尿病风险增加有统计学意义（RR, 1.15 [95% CI, 1.03-1.28], P = 0.012），而饮用100%果汁与2型糖尿病风险无显著相关性。仅在亚洲人群中观察到果汁增加2型糖尿病的风险（RR, 1.17 [95% CI 1.02-1.34], P = 0.023）。结论：饮用非100%果汁可增加2型糖尿病的发病风险。与食用全水果不同，100%果汁对2型糖尿病的风险没有有益影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Medicine 医学-医学：内科

CiteScore

6.30

自引率

3.40%

发文量

449

审稿时长

9 days

期刊介绍： The American Journal of Medicine - "The Green Journal" - publishes original clinical research of interest to physicians in internal medicine, both in academia and community-based practice. AJM is the official journal of the Alliance for Academic Internal Medicine, a prestigious group comprising internal medicine department chairs at more than 125 medical schools across the U.S. Each issue carries useful reviews as well as seminal articles of immediate interest to the practicing physician, including peer-reviewed, original scientific studies that have direct clinical significance and position papers on health care issues, medical education, and public policy.