New insights into pentoxifylline and α-lipoic acid: Co-administration with clomiphene citrate for ovulation induction in anovulatory women with polycystic ovary syndrome.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY
Ahmed A Morsy, Nagwa A Sabri, Abdelrehim M Mourad, Eman M Mojahed, Sarah F Fahmy
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Abstract

Objective: This study investigated the effects of pentoxifylline (PTX) and α-lipoic acid (ALA) on ovulation and pregnancy rates in women with clomiphene citrate (CC) resistant polycystic ovary syndrome (PCOS).

Methods: A prospective, randomized, controlled, open-label study was conducted on women with CC-resistant PCOS. In total, 120 PCOS patients were randomly assigned to four groups of 30 patients each, as follows: group 1 was the control group; group 2 received 400 mg of PTX twice daily; group 3 received 600 mg of ALA twice daily; and group 4 received a combination of PTX and ALA, following the same regimen as the previous groups. All groups were administered 150 mg of CC, the standard therapy for ovulation induction (ClinicalTrials.gov: NCT05231980).

Results: The cumulative ovulation rate was highest in the combined PTX-ALA group at 77% (23 cases), followed by the PTX group at 70% (n=21), the ALA group at 40% (n=12), and the control group at 30% (n=9) (p=0.0003). The cumulative pregnancy rates were 40% (n=12), 37% (n=11), 10% (n=3), and 3% (n=1) for the PTX-ALA, PTX, ALA, and control groups, respectively (p=0.0005). Endometrial thickness (ET) was significantly greater in the PTX group than in the control group.

Conclusion: Co-administration of PTX with CC significantly improved the ovulation rate, pregnancy rate, ET, and ovarian response to stimulation in patients with anovulatory PCOS. This combination may provide an effective, affordable, and safe treatment protocol for women with CC-resistant PCOS.

己酮茶碱和α-硫辛酸的新认识:与枸橼酸克罗米芬联合用药对无排卵多囊卵巢综合征妇女的促排卵作用。
目的:探讨己酮茶碱(PTX)和α-硫辛酸(ALA)对枸橼酸克罗米芬(CC)抗性多囊卵巢综合征(PCOS)患者排卵和妊娠率的影响。方法:一项前瞻性、随机、对照、开放标签的研究对cc抵抗性PCOS女性进行了研究。120例PCOS患者随机分为4组,每组30例,1组为对照组;2组给予PTX 400 mg,每日2次;3组每日2次,每日600 mg;第4组接受PTX和ALA联合治疗,治疗方案与前几组相同。所有组均给予150 mg CC,这是促排卵的标准疗法(ClinicalTrials.gov: NCT05231980)。结果:PTX-ALA联合组累计排卵率最高,为77%(23例),其次为PTX组为70% (n=21), ALA组为40% (n=12),对照组为30% (n=9) (p=0.0003)。PTX-ALA组、PTX组、ALA组和对照组的累计妊娠率分别为40% (n=12)、37% (n=11)、10% (n=3)和3% (n=1) (p=0.0005)。PTX组子宫内膜厚度(ET)明显高于对照组。结论:PTX与CC合用可显著提高无排卵性PCOS患者的排卵率、妊娠率、ET及卵巢对刺激的反应。这种组合可能为耐cc多囊卵巢综合征的妇女提供一种有效、负担得起和安全的治疗方案。
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CiteScore
3.30
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