Clinicopathological Characterization of Squamous Cell Lung Carcinoma Adjacent to Emphysema.

IF 3.4 4区医学 Q2 PATHOLOGY

Pathology International Pub Date : 2025-07-01 Epub Date: 2025-05-21 DOI:10.1111/pin.70023

Tetsuya Sakai, Hibiki Udagawa, Hiroki Izumi, Shigeki Umemura, Yoshitaka Zenke, Shingo Matsumoto, Kiyotaka Yoh, Naito Tomoyuki, Nakai Tokiko, Tetsuro Taki, Naoya Sakamoto, Shingo Sakashita, Motohiro Kojima, Masahiro Tsuboi, Koichi Goto, Genichiro Ishii

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Abstract

The study investigated the clinicopathological features and characteristic immune tumor microenvironment (TME) of lung squamous cell carcinoma (SqCC) adjacent to emphysematous lesions. 184 consecutive patients with peripheral-type SqCC who had undergone complete surgical resection were enrolled. The clinicopathological differences between emphysema-adjacent SqCC (EA-SqCC) and non-emphysema-adjacent SqCC (non-EA-SqCC) were examined. The immune TME, including tumor-infiltrating lymphocytes (TILs) and PD-L1 expression, was also analyzed. EA-SqCC was detected in 132 (71.7%) of the 184 patients. Patients with EA-SqCC had shorter recurrence-free survival (RFS) [median 58.2 months vs. not Reached (NR); hazard ratio (HR) 0.47; 95% CI 0.25-0.81, p < 0.01] and tended to have shorter overall survival (NR vs. NR; HR 0.47; 95% CI 0.27-1.03, p = 0.07) compared to patients with non-EA-SqCC. Evaluation of TILs in the cancer stroma showed the number of Foxp3+ TILs in the EA-SqCC group was significantly higher than that in the non-EA-SqCC group (median number 58 vs. 43, p < 0.01). However, there were no significant differences in the number of CD8 + T cells and the PD-L1 expression between the two groups. Immunosuppressive microenvironment is a characteristic feature of EA-SqCC, which may contribute to the poor prognosis of this disease.

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肺鳞状细胞癌伴肺气肿的临床病理特征。

探讨肺鳞状细胞癌（SqCC）伴肺气肿病变的临床病理特征及特征性免疫肿瘤微环境（TME）。184例接受完全手术切除的连续外周型SqCC患者被纳入研究。比较肺气肿邻近型SqCC （EA-SqCC）与非肺气肿邻近型SqCC （non-EA-SqCC）的临床病理差异。免疫TME，包括肿瘤浸润淋巴细胞（til）和PD-L1的表达也进行了分析。184例患者中有132例（71.7%）检测到EA-SqCC。EA-SqCC患者的无复发生存期（RFS）较短[中位58.2个月vs.未达到（NR）；风险比（HR） 0.47；95% CI 0.25 ~ 0.81, p

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来源期刊

Pathology International 医学-病理学

CiteScore

4.50

自引率

4.50%

发文量

102

审稿时长

12 months

期刊介绍： Pathology International is the official English journal of the Japanese Society of Pathology, publishing articles of excellence in human and experimental pathology. The Journal focuses on the morphological study of the disease process and/or mechanisms. For human pathology, morphological investigation receives priority but manuscripts describing the result of any ancillary methods (cellular, chemical, immunological and molecular biological) that complement the morphology are accepted. Manuscript on experimental pathology that approach pathologenesis or mechanisms of disease processes are expected to report on the data obtained from models using cellular, biochemical, molecular biological, animal, immunological or other methods in conjunction with morphology. Manuscripts that report data on laboratory medicine (clinical pathology) without significant morphological contribution are not accepted.