Newborn Screening for Cystic Fibrosis Is Associated With the Lowest Healthcare Costs: A 10-Year Observational Follow-Up Study in France.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Pulmonology Pub Date : 2025-05-01 DOI:10.1002/ppul.71134

Erika Guyot, Floriane Deygas, Manon Belhassen, Marjorie Berard, Eric Van Ganse, Isabelle Sermet-Gaudelus, Sabrine Tiaiba, Jean-Christophe Dubus, Isabelle Durieu, Philippe Reix

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引用次数: 0

Abstract

Objectives: This study aims to study the healthcare (HC) costs associated with cystic fibrosis (CF) in children diagnosed prenatally (ANT), through newborn screening (NBS), after birth due to meconium ileus (MI), or later based on symptoms (LS). Additionally, it seeks to clinically characterize children with CF (chCF) with different trajectories of HC costs.

Study design: A retrospective observational study was conducted on data from the French CF Registry (FCFR) and the French National Claims Database (SNDS) linked from 2006 to 2021. HC costs related to CF diagnosis circumstances were estimated per year of life among chCF up to age 10. Group-based trajectory modeling was performed to identify subgroups with similar cost trajectories.

Results: Between 2006 and 2011, data from 1065 chCF were recorded in the FCFR. Nine hundred seventy-three (91.4%) were matched with SNDS, and 779 (73.1%) had at least 10 years of follow-up. During the first year, HC costs of chCF diagnosed with NBS were lower than for those diagnosed with MI and ANT (all p < 0.05). However, by the tenth year HC were no longer different between groups. Three groups with different cost trajectories were identified. Groups with the highest costs had a lower lung function at 6 and 10 years and the lowest weight and height z-scores at 2 and 10 years (all p < 0.05).

Conclusion: NBS is associated with the lowest HC costs during the first year of life.

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新生儿囊性纤维化筛查与最低医疗费用相关：法国一项为期10年的观察性随访研究

目的：本研究旨在研究产前诊断（ANT）、新生儿筛查（NBS）、出生后诊断为胎便性肠梗阻（MI）或后来根据症状（LS）诊断为囊性纤维化（CF）的儿童的医疗保健（HC）成本。此外，它试图临床表征CF儿童（chCF）与不同轨迹的HC成本。研究设计：对2006年至2021年法国CF登记处（FCFR）和法国国家索赔数据库（SNDS）的数据进行回顾性观察性研究。与CF诊断情况相关的HC费用在chCF患者中估计至10岁。使用基于组的轨迹建模来识别具有相似成本轨迹的子组。结果：2006年至2011年间，FCFR记录了1065例chCF的数据。973例（91.4%）与SNDS匹配，779例（73.1%）随访至少10年。在第一年，诊断为NBS的chCF的HC费用低于诊断为MI和ANT的chCF（均为p）。结论：NBS与生命第一年最低的HC费用相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.