Ozonides extravirgin olive oil as an alternative to steroids in controlling proliferative behavior in penile lichen sclerosus: a comparative study in pediatric population.
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引用次数: 0
Abstract
Purpose: Lichen sclerosus (LS) is a chronic inflammatory skin condition affecting genital areas and associated with autoimmune processes. Circumcision is the primary treatment for phimosis in pediatric LS, and corticosteroids are considered the best choice for medical management. Recently, Ozoile, stable ozonides obtained through green technology from extravirgin olive oil (+ OIL®), according to a patented process, has emerged as a potential alternative with fewer long-term side effects compared to corticosteroids. The aim of the study was to compare the immune and anti-proliferative effects of the pre-operative topical use of Ozoile and corticosteroids in children with phimosis associated with LS undergoing circumcision.
Methods: Thirty-six male patients aged 3-9 years with phimosis linked to LS were divided into three groups: Group A (no pre-operative treatment), Group B (0.1% mometasone furoate), Group C (Ozoile). Post-circumcision foreskin samples were analyzed for immune cell infiltration (CD8 +, CD57 +) and proliferation markers (Ki67,p53). Non-parametric ANOVA (Kruskal-Wallis test) and Dunn tests were used and p value less than 0.05 was considered statistically significant.
Results: Histological analysis showed acanthotic epidermis and lymphoid infiltrate in Group A, with reduced lymphocytes and markers in Groups B and C. Groups B and C showed no significant differences in CD8 + and CD57 + lymphocytes (p = 0.34, p = 0.54, respectively), but Group C had significantly lower proliferation markers Ki-67 (p = 0.035) and p53 (p = 0.039).
Conclusion: Both Ozoile and corticosteroids reduced inflammatory and proliferative activity in pediatric LS patients. Ozoile showed superior suppression of proliferative markers, suggesting potential benefits for patients at risk of steroid-related side effects. Further research is needed to confirm long-term benefits.
期刊介绍：
Pediatric Surgery International is a journal devoted to the publication of new and important information from the entire spectrum of pediatric surgery. The major purpose of the journal is to promote postgraduate training and further education in the surgery of infants and children.
The contents will include articles in clinical and experimental surgery, as well as related fields. One section of each issue is devoted to a special topic, with invited contributions from recognized authorities. Other sections will include:
-Review articles-
Original articles-
Technical innovations-
Letters to the editor
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