Increased preoperative levels of circulating erythrocytic hemoglobin might predict high-grade histology (WHO grade 2-3) in falcine and parasagittal meningiomas.

IF 1.2 4区医学 Q4 CLINICAL NEUROLOGY

Journal of neurosurgical sciences Pub Date : 2025-05-21 DOI:10.23736/S0390-5616.24.06371-9

Filippo Gagliardi, Silvia Snider, Pierfrancesco DE Domenico, Matteo Braga, Lina R Barzaghi, Gianluca Nocera, Marcella Callea, Maria R Terreni, Pietro Mortini

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引用次数: 0

Abstract

Background: Falcine/parasagittal lesions account for the largest rate of high-grade (WHO grade 2-3) lesions. The ability to preoperatively estimate the tumors' grade and outcome would be of great value in customizing treatment.

Methods: This is a single-center, retrospective study designed to assess the pre-operative peripheral blood markers' diagnostic and prognostic role in patients harboring falcine (FM) and parasagittal (PM) high-grade meningiomas. N=116 patients undergoing surgical resection were included. A propensity score-matched analysis accounted for gender imbalances in low-grade (LG) vs. high-grade (HG) cohorts.

Results: Seventy-three (N.=73) FM (63%) and 43 PM (37%) lesions were included. Patients harboring HG lesions showed significantly higher Hb levels than LG (mean 14.5±1.40 vs. 13.5±1.16 g/dL, P<0.001). Multivariate analysis controlling for demographics, lesion characteristics, blood markers, and steroid dose confirmed preoperative Hb as an independent predictive value of lesion grade (OR 1.75, 95% CI:1.01-3.07, P=0.04). Accordingly, patients showing increased Hb levels >15.4 g/dL achieved shorter OS (60.4 months, 95% CI: 14.7-106.1 vs. 134.7 months, 95% CI: 111.2-158.2) compared to patients with lower Hb values, P<0.001. Data were confirmed in matched cohorts.

Conclusions: Increased levels of circulating erythrocytic hemoglobin might be independent predictors for high-grade histology and be associated with shorter overall survival in falcine and parasagittal meningiomas.

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术前循环红细胞血红蛋白水平升高可能预示镰状和旁矢状脑膜瘤的高级别组织学（WHO分级2-3）。

背景：镰状/旁矢状面病变占高级别（WHO 2-3级）病变的最大比例。术前评估肿瘤分级和预后的能力将对定制治疗具有重要价值。方法：这是一项单中心回顾性研究，旨在评估术前外周血标志物在镰状（FM）和旁矢状（PM）高级别脑膜瘤患者中的诊断和预后作用。纳入116例手术切除患者。倾向评分匹配分析解释了低级别（LG）与高级别（HG）队列中的性别不平衡。结果：包括73例FM（63%）和43例PM（37%）病变。与Hb值较低的患者相比，HG病变患者的Hb水平明显高于LG(平均14.5±1.40比13.5±1.16 g/dL, P15.4 g/dL的OS较短（60.4个月，95% CI: 14.7-106.1比134.7个月，95% CI: 111.2-158.2）。结论：循环红细胞血红蛋白水平升高可能是高级别组织学的独立预测因子，与镰状和旁矢状脑膜瘤较短的总生存期相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of neurosurgical sciences CLINICAL NEUROLOGY-SURGERY

CiteScore

3.00

自引率

5.30%

发文量

202

审稿时长

>12 weeks

期刊介绍： The Journal of Neurosurgical Sciences publishes scientific papers on neurosurgery and related subjects (electroencephalography, neurophysiology, neurochemistry, neuropathology, stereotaxy, neuroanatomy, neuroradiology, etc.). Manuscripts may be submitted in the form of ditorials, original articles, review articles, special articles, letters to the Editor and guidelines. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work.