Kanza Rahali, Atabak Ghanizadeh Tabriz, Dennis Douroumis
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引用次数: 0
Abstract
Microfluidic arrays have been successfully implemented for the design and development of liposome nanoparticles. In this study we have applied a Quality by Design (QbD) approach to investigate the effect of 3D printed Tesla microfluidic designs (direct and serpentine shape) on the liposome nanoparticles in comparison with conventional ultrasonication methodology. Critical processing parameters (CPP) such as the shape, length and channel width of the Tesla arrays were also studied. Furthermore, the effect of critical material attributes (CMA), including the length of the phosphatidylcholine (PC) carbon chain and the lipid:cholesterol ratio on the produced nanoparticles was investigated. The obtained findings revealed that both CPP and CMA play a key role in the formation of liposome nanoparticles. The liposome size was decreasing with a descending order for plain array > Tesla (serpentine) > Tesla (direct) > ultrasonication. However, improved Tesla arrays with narrow channel width (200 μm) produced the smallest liposome particle size (74 nm). The PC carbon chain length was critical for the obtained particle size where Lipoid S75 produced smaller nanoparticles when compared to Lipoid E80. The increase of cholesterol content resulted in liposome size reduction and decreased zeta-potential.
期刊介绍:
The Journal of Liposome Research aims to publish original, high-quality, peer-reviewed research on the topic of liposomes and related systems, lipid-based delivery systems, lipid biology, and both synthetic and physical lipid chemistry. Reviews and commentaries or editorials are generally solicited and are editorially reviewed. The Journal also publishes abstracts and conference proceedings including those from the International Liposome Society.
The scope of the Journal includes:
Formulation and characterisation of systems
Formulation engineering of systems
Synthetic and physical lipid chemistry
Lipid Biology
Biomembranes
Vaccines
Emerging technologies and systems related to liposomes and vesicle type systems
Developmental methodologies and new analytical techniques pertaining to the general area
Pharmacokinetics, pharmacodynamics and biodistribution of systems
Clinical applications.
The Journal also publishes Special Issues focusing on particular topics and themes within the general scope of the Journal.