Diagnosis, management and prevention of loiasis: guideline of the German Society for Tropical Medicine, Travel Medicine, and Global Health (DTG).

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2025-06-01 Epub Date: 2025-05-21 DOI:10.1007/s15010-024-02443-2

Michael Ramharter, Stefan Schlabe, Marc P Hübner, Pia Michelitsch, Florian Kurth, Sabine Bélard, Tamara Nordmann, Saskia Dede Davi

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引用次数: 0

Abstract

Loiasis is a complex filarial infection endemic in Central Africa and parts of West Africa. Loa loa is transmitted by the deer fly Chrysops dimidiata and C. silacea. The clinical manifestation of the disease is highly variable ranging from asymptomatic infection, symptomatic disease, to life-threatening complications. The diagnosis of L. loa infection is challenging due to a significant proportion of occult infections and a lack of reliable point of care tests. While diethylcarbamazine is the gold standard for curative treatment in many non-endemic countries, its use is limited in endemic regions due to its propensity for severe adverse drug reactions that may occasionally lead to life threatening complications. Alternative treatment regimens have specific indications and limitations in the treatment of loiasis. In this guideline, issued by the German Society for Tropical Medicine, Travel Medicine, and Global Health, recommendations for the diagnosis, management, treatment, and prevention of loiasis are provided based on the currently available best evidence, and gaps in our understanding are highlighted.

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风湿病的诊断、管理和预防：德国热带医学、旅行医学和全球卫生学会（DTG）指南。

路易丝虫病是中非和西非部分地区流行的一种复杂的丝虫病。Loa Loa是由鹿蝇Chrysops dimidiata和C. silacea传播的。该病的临床表现多种多样，从无症状感染到有症状的疾病，再到危及生命的并发症。由于相当大比例的隐匿性感染和缺乏可靠的护理点检测，L. loa感染的诊断具有挑战性。虽然二乙基卡马嗪在许多非流行国家是治疗性治疗的金标准，但在流行地区的使用受到限制，因为它容易产生严重的药物不良反应，有时可能导致危及生命的并发症。替代治疗方案有特定的适应症和局限性在治疗风疹。在这份由德国热带医学、旅行医学和全球卫生学会发布的指南中，根据目前可获得的最佳证据提供了诊断、管理、治疗和预防风湿病的建议，并强调了我们理解中的差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.