Epigenetic Modifications in Sensorineural Hearing Loss: Protective Mechanisms and Therapeutic Potential.

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current Medical Science Pub Date : 2025-05-21 DOI:10.1007/s11596-025-00049-9

Jia-Huan Li, Chang Liu, Si-Yu Qiu, Shi-Mei Zheng, Ying-Zi He

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Abstract

Hearing loss, which currently affects more than 430 million individuals globally and is projected to exceed 700 million by 2050, predominantly manifests as sensorineural hearing loss (SNHL), for which existing technologies such as hearing aids and cochlear implants fail to restore natural auditory function. Research focusing on protecting inner ear hair cells (HCs) from harmful factors through the regulation of epigenetic modifications has gained significant attention in otology for its role in regulating gene expression without altering the DNA sequence, suggesting potential strategies for preventing and treating SNHL. By synthesizing relevant studies on the inner ear, this review summarizes the emerging roles of histone modifications, DNA methylation, and noncoding RNAs in HC damage, with a focus on their therapeutic potential through epigenetic modulation. Moreover, this review examines the therapeutic potential of epigenetic regulation for the prevention and treatment of SNHL, emphasizing the application of small-molecule epigenetic compounds and their efficacy in modulating gene expression to preserve and restore auditory function.

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感音神经性听力损失的表观遗传修饰：保护机制和治疗潜力。

听力损失目前影响着全球超过4.3亿人，预计到2050年将超过7亿人。听力损失主要表现为感音神经性听力损失（SNHL），目前的助听器和人工耳蜗等技术无法恢复自然听觉功能。通过表观遗传修饰调控内耳毛细胞（HCs）免受有害因素影响的研究，因其在不改变DNA序列的情况下调节基因表达的作用而受到耳科学的重视，为预防和治疗SNHL提供了潜在的策略。本文通过对内耳相关研究的综合，综述了组蛋白修饰、DNA甲基化和非编码rna在HC损伤中的新作用，并重点介绍了它们通过表观遗传调控的治疗潜力。此外，本文综述了表观遗传调控在预防和治疗SNHL中的治疗潜力，重点介绍了小分子表观遗传化合物的应用及其在调节基因表达以保护和恢复听觉功能方面的功效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Medical Science Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.70

自引率

0.00%

发文量

126

期刊介绍： Current Medical Science provides a forum for peer-reviewed papers in the medical sciences, to promote academic exchange between Chinese researchers and doctors and their foreign counterparts. The journal covers the subjects of biomedicine such as physiology, biochemistry, molecular biology, pharmacology, pathology and pathophysiology, etc., and clinical research, such as surgery, internal medicine, obstetrics and gynecology, pediatrics and otorhinolaryngology etc. The articles appearing in Current Medical Science are mainly in English, with a very small number of its papers in German, to pay tribute to its German founder. This journal is the only medical periodical in Western languages sponsored by an educational institution located in the central part of China.