Aberrant cerebral activity in patients with unruptured intracranial aneurysm: a resting-state functional MRI study.

IF 2.7 3区医学 Q1 ANATOMY & MORPHOLOGY

Brain Structure & Function Pub Date : 2025-05-20 DOI:10.1007/s00429-025-02934-4

Wei Li, Weijie Fan, Si Zhang, Haiyu Zhang, Dong Zhang, Li Wen

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引用次数: 0

Abstract

Patients carrying unruptured intracranial aneurysm (UIA) often experience emotional alterations and cognitive impairments. While the specific mechanisms underlying these impairments are still not fully understood. The study measured the amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) to investigate the abnormal brain functional alterations in 49 UIA patients compared with 50 healthy controls, and also analyzed the correlations among neuroimaging indices, the clinical data, and the neuropsychological test results. UIA patients exhibited more active brain region activity in the right hippocampus than the healthy group and showed negatively activated brain regions, including the cuneus, left paracentral lobule, and right postcentral gyrus. Furthermore, the strength of FC decreased in the bilateral middle cingulate gyrus; right superior temporal gyrus and insula; and left parahippocampal gyrus, fusiform gyrus, lingual gyrus, inferior frontal gyrus, and middle frontal gyrus. The abnormal activities in the aforementioned brain regions were closely linked to worse performance in emotion and cognition. The study presents a potential neuroimaging-based mechanism of brain function that could explain the emotional alterations and cognitive impairments in UIA patients.

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未破裂颅内动脉瘤患者的异常脑活动：静息状态功能MRI研究。

患有未破裂颅内动脉瘤（UIA）的患者通常会经历情绪改变和认知障碍。而这些损伤背后的具体机制仍未完全了解。本研究通过测量低频波动幅度（ALFF）和功能连通性（FC），探讨49例UIA患者与50例健康对照者的脑功能异常改变，并分析神经影像学指标、临床资料和神经心理测试结果之间的相关性。UIA患者在右侧海马区表现出比健康组更活跃的脑区活动，并表现出负激活的脑区，包括楔叶、左侧中央旁小叶和右侧中央后回。双侧扣带中回FC强度下降；右侧颞上回和脑岛；左海马旁回，梭状回，舌回，额下回，额中回。上述大脑区域的异常活动与情绪和认知方面的较差表现密切相关。该研究提出了一种潜在的基于神经影像学的脑功能机制，可以解释UIA患者的情绪改变和认知障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Structure & Function 医学-解剖学与形态学

CiteScore

6.00

自引率

6.50%

发文量

168

审稿时长

8 months

期刊介绍： Brain Structure & Function publishes research that provides insight into brain structure−function relationships. Studies published here integrate data spanning from molecular, cellular, developmental, and systems architecture to the neuroanatomy of behavior and cognitive functions. Manuscripts with focus on the spinal cord or the peripheral nervous system are not accepted for publication. Manuscripts with focus on diseases, animal models of diseases, or disease-related mechanisms are only considered for publication, if the findings provide novel insight into the organization and mechanisms of normal brain structure and function.