SiO2-Coated ZnO for Photothermal and Photodynamic Antibacterial Applications in Bone Repair.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Yanxia Zhang, Nazakaiti Imamaimaiti, Xiaohui Tang, Jua Kim, Tao Jiang, Huiting Fu, Haobo Pan, Yingbo Wang
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引用次数: 0

Abstract

Poly(L-lactic acid) (PLLA) is a promising material for bone substitutes due to its biodegradability and biocompatibility. However, its limited osteogenic activity and antibacterial properties restrict its applications. To address these challenges, this study develops PLLA/SiO2@ZnO/PDA/PLL composite fibrous materials using an approach that integrates electrospinning with ultrasonic techniques. The composite exhibits photothermal antibacterial functionality and osteoinductive properties. The material demonstrates excellent hydrophilicity, sustained-release capability, and antibacterial activity. Upon near-infrared light exposure, Zn2+ ions are released, disrupting bacterial membranes via electrostatic interactions and lipid peroxidation induced by reactive oxygen species. This dual mechanism leads to bacterial membrane rupture and biofilm degradation. Zn2+ ions also interfere with bacterial respiratory enzymes, disrupting the electron transfer process and achieving efficient antibacterial effects. The composite further shows outstanding biocompatibility and osteoinductivity, promoting vascular endothelial cell and osteoblast adhesion and enhancing calcium-phosphate salt deposition. In vivo studies confirm its safety with no significant toxicity or adverse effects on tissues and organs. This PLLA/SiO2@ZnO/PDA/PLL composite offers significant potential for repairing infected bone tissue and provides a strong foundation for future applications in bone tissue engineering.

二氧化硅包覆ZnO在骨修复中的光热和光动力抗菌应用
聚l -乳酸(PLLA)具有生物可降解性和生物相容性,是一种很有前途的骨替代物材料。然而,其有限的成骨活性和抗菌性能限制了其应用。为了解决这些挑战,本研究采用静电纺丝与超声波技术相结合的方法开发了PLLA/SiO2@ZnO/PDA/PLL复合纤维材料。该复合材料具有光热抗菌功能和骨诱导特性。该材料具有优异的亲水性、缓释能力和抗菌活性。在近红外光照射下,Zn2+离子被释放,通过静电相互作用和活性氧诱导的脂质过氧化作用破坏细菌膜。这种双重机制导致细菌膜破裂和生物膜降解。Zn2+离子还会干扰细菌的呼吸酶,破坏电子传递过程,达到有效的抗菌效果。复合材料进一步表现出良好的生物相容性和成骨性,促进血管内皮细胞和成骨细胞的粘附,增强磷酸钙沉积。体内研究证实其安全性,对组织和器官没有明显的毒性或不良影响。这种PLLA/SiO2@ZnO/PDA/PLL复合材料具有修复感染骨组织的巨大潜力,为未来在骨组织工程中的应用奠定了坚实的基础。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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