Hesperidin Derivatives Contained Hydrogel Dressing for Photothermal Treatment of Melanoma and Postoperative Tissue Regeneration.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2025-05-21 DOI:10.1021/acsabm.5c00633

Jiaqian He, Zheng Zhou, Wenxiang Zhu, Xin Chen, Shuai Zhu, Jingjing Sun, You Zuo, Mengni Yang, Mengyi Yu, Lingxiu Yang, Jiajie Lei, Wenjia Shao, Xiaoli He, Hairong Liu

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引用次数: 0

Abstract

Melanoma is a severe malignant skin tumor. It is crucial to effectively eliminate melanoma and promote rapid and healthy regeneration of postoperative tissue defects. Herein, hesperidin derivatives (HD) have been developed as the bioactive components of hydrogels that are capable of ablating melanoma via photothermal therapy (PTT) and promoting tissue regeneration. HD have been prepared by heating hesperidin alkaline solution followed by dialysis and lyophilization, and GelMA hydrogels encapsulating HD kill cancer cells and bacteria under near-infrared (NIR) irradiation. The in vitro test and in vivo transcriptomic analysis confirmed that the HD containing GelMA hydrogels induce the immunogenic cell death (ICD) effect of tumor cells by significantly upregulating chemokine-related, cytokine-related, and apoptosis-related genes, thereby enhancing therapeutic efficacy. In a mouse model of infected skin wounds, the HD containing hydrogels under 808 nm light irradiation effectively promoted wound repair. This was achieved through accelerated wound closure and enhanced skin regeneration, mediated by increased angiogenesis and collagen deposition. In conclusion, the HD containing hydrogels provide a new strategy for the clinical treatment of melanoma and postoperative tissue defect repair following operative resection of cancer.

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含橙皮苷衍生物的水凝胶敷料用于黑色素瘤光热治疗和术后组织再生。

黑色素瘤是一种严重的恶性皮肤肿瘤。有效消除黑色素瘤，促进术后组织缺损快速健康再生至关重要。在此，橙皮苷衍生物（HD）已被开发为能够通过光热疗法（PTT）消融黑色素瘤并促进组织再生的水凝胶的生物活性成分。通过加热橙皮苷碱性溶液，透析和冻干制备HD，包裹HD的GelMA水凝胶在近红外（NIR）照射下杀死癌细胞和细菌。体外实验和体内转录组学分析证实，含GelMA的HD水凝胶通过显著上调趋化因子相关基因、细胞因子相关基因和凋亡相关基因，诱导肿瘤细胞的免疫原性细胞死亡（ICD）效应，从而提高治疗效果。在小鼠感染皮肤创面模型中，含HD水凝胶在808 nm光照射下有效促进创面修复。这是通过加速伤口愈合和增强皮肤再生来实现的，介导的血管生成和胶原沉积增加。总之，含HD水凝胶为黑色素瘤的临床治疗和肿瘤切除术后组织缺损修复提供了一种新的策略。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.