Continuous Depletion of Tetrahydrocannabinol From Cannabis Extract Through Simulated Moving Bed Chromatography Using Green Mobile Phase

IF 2.8 3区工程技术 Q2 CHEMISTRY, ANALYTICAL

Journal of separation science Pub Date : 2025-05-22 DOI:10.1002/jssc.70175

Greta Compagnin, Chiara De Luca, Chiara Nosengo, Giorgia Greco, Martina Catani, Alberto Cavazzini, Yannick Krauke, Simona Felletti

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引用次数: 0

Abstract

The interest toward greener and more sustainable chemical processes is constantly growing, especially in chemical industries, where there is an urgent need to reduce the waste on one hand, and to replace not environmentally friendly organic solvents, on the other.

One of the current challenges in industrial processes is the depletion of the psychoactive cannabinoid tetrahydrocannabinol (THC) from hemp extracts. Indeed, current legislations impose that THC in hemp products must meet defined concentration limits or, in some cases, it must be completely removed. In the present study, the continuous depletion of THC has been performed through simulated moving bed chromatography operated with a fully green mobile phase, made of water and ethanol. This process permits to overcome the limits and drawbacks of available purification methods, based on toxic solvents and traditional single column chromatography.

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绿色流动相模拟移动床色谱法连续萃取大麻提取物中的四氢大麻酚

对更绿色和更可持续的化学过程的兴趣不断增长，特别是在化学工业中，一方面迫切需要减少浪费，另一方面迫切需要取代不环保的有机溶剂。目前工业过程中的挑战之一是从大麻提取物中消耗精神活性大麻素四氢大麻酚（THC）。事实上，目前的立法规定大麻产品中的四氢大麻酚必须达到规定的浓度限制，或者在某些情况下，必须完全去除。在本研究中，四氢大麻酚的连续耗尽是通过模拟移动床色谱法进行的，采用全绿色流动相，由水和乙醇组成。这个过程允许克服现有的净化方法的限制和缺点，基于有毒溶剂和传统的单柱色谱法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of separation science 化学-分析化学

CiteScore

6.30

自引率

16.10%

发文量

408

审稿时长

1.8 months

期刊介绍： The Journal of Separation Science (JSS) is the most comprehensive source in separation science, since it covers all areas of chromatographic and electrophoretic separation methods in theory and practice, both in the analytical and in the preparative mode, solid phase extraction, sample preparation, and related techniques. Manuscripts on methodological or instrumental developments, including detection aspects, in particular mass spectrometry, as well as on innovative applications will also be published. Manuscripts on hyphenation, automation, and miniaturization are particularly welcome. Pre- and post-separation facets of a total analysis may be covered as well as the underlying logic of the development or application of a method.