A Dual-Functional Nano-Based Platform: Dialdehyde-β-Cyclodextrin-Modified Cellulose Nanowhiskers for Enhanced Curcumin Delivery and Efficient Dye Removal

IF 2.2 4区 工程技术 Q1 MATERIALS SCIENCE, TEXTILES
Respina Arefizadeh, Abbas Dadkhah Tehrani
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Abstract

In the current study, dialdehyde-β-cyclodextrin (DA-β-CD) grafted cellulose nanowhisker (β-CD-CNW) was developed as a new platform for JGB (Janus Green B) dye removal as well as Curcumin (CUR) delivery. While CNWs and their derivatives typically adsorb cationic/anionic dyes through electrostatic interactions, β-CD-CNW enables unique host–guest complexation that facilitates: (1) dye adsorption regardless of molecular charge (58 mg/g capacity for JGB), (2) effective encapsulation of hydrophobic drugs (85% CUR release over 72h), and (3) potential selective adsorption based on molecular size/shape. DA-β-CD, unlike, β-CD could decorated at the surface of aminated CNW through a very simple and straightforward reaction. The results showed that despite its partial ring opening during preparation using periodate oxidation, DA-β-CD still maintains its ability to form an inclusion complex. The ability of DA-β-CD to form an inclusion complex was assessed simply by color change of phenolphthalein (Php) during complexation by the naked eye. Evaluation of modified CNW demonstrated successful CUR encapsulation and controlled release profiles for curcumin as a hydrophobic drug. Furthermore, it showed suitable antioxidant activity (70%). In addition, it exhibited enhanced dye removal efficacy with about 58mg/g sorption capacity and the kinetics study showed that the adsorption rate of JGB dye aligns with the pseudo-second-order kinetic model. This research highlights the dual functionality of DA-β-CD decorated cellulose nanowhiskers in drug delivery and dye removal, indicating modified CNW may be considered for sustainable applications in pharmaceuticals and environmental science.

Graphical Abstract

双功能纳米平台:双醛-β-环糊精修饰纤维素纳米晶须增强姜黄素传递和高效染料去除
在本研究中,开发了双醛-β-环糊精(DA-β-CD)接枝纤维素纳米须(β-CD-CNW)作为JGB (Janus Green B)染料去除和姜黄素(CUR)递送的新平台。虽然cnw及其衍生物通常通过静电相互作用吸附阳离子/阴离子染料,但β-CD-CNW能够实现独特的主-客体络合,从而促进:(1)不考虑分子电荷的染料吸附(JGB的容量为58 mg/g),(2)对疏水药物的有效包被(72小时内85%的CUR释放),以及(3)基于分子大小/形状的潜在选择性吸附。与DA-β-CD不同,β-CD可以通过非常简单直接的反应在胺化CNW表面进行修饰。结果表明,尽管DA-β-CD在高碘酸盐氧化制备过程中部分开环,但仍保持了形成包合物的能力。DA-β-CD形成包合物的能力仅通过肉眼观察酚酞(Php)在络合过程中的颜色变化来评价。对改性CNW的评价表明,姜黄素作为疏水药物成功地进行了CUR包封和控释。此外,它还具有较好的抗氧化活性(70%)。吸附量约为58mg/g,对染料的去除效果较好。动力学研究表明,JGB染料的吸附速率符合准二级动力学模型。这项研究突出了DA-β-CD修饰纤维素纳米晶须在药物传递和染料去除方面的双重功能,表明改性CNW可能在制药和环境科学中得到可持续的应用。图形抽象
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来源期刊
Fibers and Polymers
Fibers and Polymers 工程技术-材料科学:纺织
CiteScore
3.90
自引率
8.00%
发文量
267
审稿时长
3.9 months
期刊介绍: -Chemistry of Fiber Materials, Polymer Reactions and Synthesis- Physical Properties of Fibers, Polymer Blends and Composites- Fiber Spinning and Textile Processing, Polymer Physics, Morphology- Colorants and Dyeing, Polymer Analysis and Characterization- Chemical Aftertreatment of Textiles, Polymer Processing and Rheology- Textile and Apparel Science, Functional Polymers
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