Electrochemically facilitated synthesis of chlorotoluene

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-05-20 DOI:10.1016/j.tetlet.2025.155643

Bowen Liu , Yumei Zhu , Xue Qin , Fang Li

引用次数: 0

Abstract

This research introduces a green and efficient electrochemical method for toluene chlorination using a saturated NaCl solution as the chlorine source and electrolyte. Through systematic optimization of parameters, including electrode materials, electrolysis duration, current intensity, and chlorine sources, a 97.4 % conversion rate was achieved at a current of 500 mA for 6 h. The combination of FeCl₃ and allyl mercaptan significantly enhanced ortho-selectivity (96.4 %). The method is applicable to multiple aromatic hydrocarbons. Compared with traditional methods, it offers notable advantages including efficient, environmentally friendly characteristics and adjustable conditions, which provides useful references for organic synthesis research and potential applications.

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电化学催化合成氯甲苯

介绍了一种以饱和NaCl溶液为氯源和电解质的绿色高效的甲苯氯化电化学方法。通过对电极材料、电解时间、电流强度、氯源等参数的系统优化，在500 mA电流下，反应时间为6 h，转化率达到97.4%。FeCl₃与烯丙基硫醇的结合显著提高了正选择性（96.4%）。该方法适用于多种芳烃。与传统方法相比，该方法具有高效、环保、条件可调等显著优势，为有机合成研究和潜在应用提供了有益参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.