1,2-Aminoalkylacylation of styrenes by cooperative NHC/photoredox dual catalysis

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2025-04-18 DOI:10.1080/00397911.2025.2486106

Lili Wu (Formal analysis Investigation Methodology Writing – original draft) , Chengming Wang (Conceptualization Funding acquisition Project administration Supervision Writing – review & editing)

引用次数: 0

Abstract

A novel visible-light-mediated 1,2-aminoalkylacylation reaction of styrenes with α-silyl-protected tertiary amines and acyl fluorides has been developed for the efficient construction of γ-aminoketones. This transformation employs a synergistic dual catalyst system, combining the benefits of N-heterocyclic carbene catalysis and photoredox catalysis, enabling the reaction to proceed under mild conditions.

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NHC/光氧化还原双催化作用下苯乙烯的1,2-氨基烷基化反应

建立了一种新的可见光介导的苯乙烯与α-硅基保护叔胺和酰基氟化物的1,2-氨基烷基化反应，以高效构建γ-氨基酮。该转化采用协同双催化剂体系，结合了n -杂环碳催化和光氧化还原催化的优点，使反应在温和的条件下进行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.